CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6.

CD28受体家族（英語： CD28 family receptors ）是一类表达在免疫细胞 表面的受體，CD28家族也是免疫球蛋白超家族的一员 [1] 。 家族的两个成员，CD28和ICOS，能作为T细胞的阳性激活受体，另外三个BTLA [2] 、CTLA-4和PD-1则起抑制作用 [1] ，CD28家族受体的配体通常为B7蛋白 ...

CD28受體家族（英語： CD28 family receptors ）是一類表達在免疫細胞 表面的受體，CD28家族也是免疫球蛋白超家族的一員 [1] 。 家族的兩個成員，CD28和ICOS，能作為T細胞的陽性激活受體，另外三個BTLA [2] 、CTLA-4和PD-1則起抑制作用 [1] ，CD28家族受體的配體通常為B7 ...

CD28 family receptors are a group of regulatory cell surface receptors expressed on immune cells. The CD28 family in turn is a subgroup of the immunoglobulin superfamily. [1] Two family members, CD28 and ICOS, act as positive regulators of T cell function while another three, BTLA, [2] CTLA-4 and PD-1 act as inhibitors. [1] .

CD28是 T淋巴细胞 表面表达的 共刺激 分子，对 T细胞 的活化起到重要作用。 它与APC（抗原递呈细胞）上的B7分子结合，介导 T细胞 的共刺激并促进其存活、增殖以及产生 细胞因子。 初始T细胞 的完全活化通常需要三个信号，第一信号是抗原和抗原受体的结合， 第二信号 是 共刺激信号，第三信号是 细胞因子 信号。 CD28作为共刺激分子，参与了第二信号的接收。 当 DC （树突状细胞）表面的特异 pMHC 结合了初始Th细胞（辅助性T细胞）或 Tc细胞 （细胞毒性T细 …

其中，cd28、cd27、cd134（ox40）和cd137（4-1bb）等共刺激分子信号域都已经成功通过了测试 [49] 。 该结构域的具体种类构造同样定义了嵌合抗原受体t细胞的代。第一代受体只包括cd3-ζ的细胞质域 [4] 。第二代受体在此之上增加了一个如cd28或4-1bb的共刺激域。

2024年12月24日 · CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include Immunodeficiency 123 With Hpv-Related Verrucosis and Classic Mycosis Fungoides. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer.

CD28 is a glycoprotein that is constitutively expressed on both resting and activated T cells. It plays a crucial role in T cell activation and signaling, promoting cell cycle entry and the production of various cytokines and chemokines. CD28 also induces the expression of other costimulatory and regulatory molecules.

2017年10月23日 · CD28 provides an essential costimulatory signal for T cell activation, and its function is critical in antitumor immunity. However, the molecular mechanism of CD28 transmembrane signaling...

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor can provide a potent signal for the production of various interleukins (IL-6 in particular).

2021年7月8日 · In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond ...

CD28 ligation leads to unique epigenetic, transcriptional, and post-translational changes in T cells that cannot be recapitulated by TCR ligation alone. We discuss the function of CD28 and its ligands in both effector and regulatory T cells. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis.

CD28 is a 44-kDa disulfide-linked glycoprotein expressed constitutively in the majority of CD4+ and CD8 + T cells. It binds to CD80 (B7.1) and CD86 (B7.2), expressed on the surface of APCs. The interaction of CD28 with its ligands promotes T …

CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and survival. When T cells are stimulated through CD28 in conjunction with the T-cell receptor (TCR), it enhances the production of various interleukins, particularly IL-6.

CD28 (cluster of differentiation 28) is a 44 kDa homodimeric transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD28 is mainly expressed on T cells, including thymocytes and may be found on plasmablasts.

Cytotoxic T lymphocyte antigen-4 reverses the activity of the T cell co-stimulator receptor called CD28. CD28 and CTLA-4 share similar ligands called CD80 (B7.1) and CD86 (B7.2).

CD28 is not normally expressed on B cells or plasma cells. It is the major costimulatory molecule on T cells. However Shapiro et al. (2001) note that more than 90% of extramedullary myelomas express CD28. Shapiro et al. (2001) note that on T cells CD28 activation up regulates transcription of...

CD28 is a most effective and co-stimulatory receptor expressed on T cells and binds to ligand CD80/CD86. CD28 is important for the proliferation and efficacy of T-cell immune responses. Chromosome 2q33.2 is the location of the CD28 gene.

2007年4月27日 · Use the links below as well as the links to the gene information pages above to check existing GO annotation for CD28. GO annotation for a particular gene in a set of orthologous genes will vary between species depending upon the experimental evidence available, annotation completeness, and fundamental differences in biology.

2005年1月1日 · The CD28 family of receptors (CD28, cytotoxic T-lymphocyte–associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response.