Crry/p65, a membrane complement regulatory protein, has
2000年5月1日 · In this study, we describe a novel function for the mouse RCA type I membrane protein Crry/p65 as a costimulatory molecule in CD4+ T cell activation. This is shown by increased anti-CD3-induced proliferation of CD4+ spleen T lymphocytes in the presence of the Crry/p65-specific mAb P3D2.
Transient and Selective NF-κB p65 Serine 536 Phosphorylation …
2004年5月15日 · The role of lipid raft formation for CD3/CD28-induced p65 serine 536 phosphorylation was investigated upon pretreatment of T cells with either the cholesterol synthesis inhibitor nystatin or the cholesterol-depleting drug methyl-β-cyclodextrin, followed by the analysis of costimulation-induced p65 phosphorylation.
Differential regulation of p65 and c-Rel NF-κB transactivating …
2007年3月1日 · It has been shown that phosphorylation of p65/RelA and c-Rel plays a role in the regulation of transcriptional activity of NF-κB independent on IκB degradation. In this study, we show that anti CD3/CD28 activation induces the transactivation activity of both p65/RelA and c-Rel in T cells using Gal4 dependent assays.
Stepwise phosphorylation of p65 promotes NF-κB activation …
2016年5月25日 · Synergistic signalling is defective in X-linked lymphoproliferative disease (XLP1) NK cells entailing 2B4 dysfunction and required for p65 phosphorylation by PI3K-Akt signal, suggesting stepwise...
Crry/p65, a Membrane Complement Regulatory Protein, Has …
2000年5月1日 · In this study, we describe a novel function for the mouse RCA type I membrane protein Crry/p65 as a costimulatory molecule in CD4 + T cell activation. This is shown by increased anti-CD3-induced proliferation of CD4 + spleen T lymphocytes in the presence of the Crry/p65-specific mAb P3D2.
Transient CD3/CD28-induced NF-p65 C-terminal ... - ResearchGate
Phosphorylation of endogenous proteins was revealed by phosphospecific Abs detecting phosphorylated forms of p65 (serine 536) and IB (serines 32 and 36), as well as activation loop...
It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation
2002年8月1日 · CD28 can provide a signal that is at least partially distinct from that delivered by the T cell receptor (TCR)–CD3 complex. Several lines of evidence indicate that the nuclear factor (NF)-κB pathway is perhaps the most relevant biochemical or transcriptional target for the costimulatory activity of CD28.
Controlling NF-κB activation in T cells by costimulatory receptors ...
2006年1月13日 · The NF-κB DNA-binding subunit c-Rel is selectively required for CD28-induced chromatin remodelling and nucleosome positioning across the IL-2 promoter, while p65 does not participate in this ...
Differential regulation of p65 and c-Rel NF-kappaB ... - PubMed
It has been shown that phosphorylation of p65/RelA and c-Rel plays a role in the regulation of transcriptional activity of NF-kappaB independent on IkappaB degradation. In this study, we show that anti CD3/CD28 activation induces the transactivation activity of both p65/RelA and c …
Differential regulation of p65 and c-Rel NF-κB ... - ScienceDirect
2007年3月1日 · It has been shown that phosphorylation of p65/RelA and c-Rel plays a role in the regulation of transcriptional activity of NF-κB independent on IκB degradation. In this study, we show that anti CD3/CD28 activation induces the transactivation activity of both p65/RelA and c-Rel in T cells using Gal4 dependent assays.