CD33 is a transmembrane receptor of the innate immune system that is expressed on the surface of peripheral monocytes and microglial cells in the brain. CD33 was first implicated in …

2019年5月10日 · The microglial receptor CD33 opposes the effects of TREM2 signaling, and may make a more amenable target because it would be inhibited rather than activated (see Part 5 …

2024年4月19日 · One was an antibody, discovered in the blood of cognitively sharp centenarians, that blocks the inhibitory receptor CD33, thus freeing microglia to carry out their protective …

CD33, a transmembrane receptor of the innate immune system, is expressed on the surface of microglial cells. Genome-wide association studies (GWAS) have linked variants in CD33 to …

2013年8月22日 · Role of CD33 in Alzheimer's Rare variants in the CD33 gene that protect against Alzheimer's disease (right panel) lead to reduced CD33 expression or alter the binding of …

2022年7月14日 · CD33 is also expressed on peripheral blood monocytes. Findings In March 2019, AL003 entered the clinic with a 54-person trial being run at six sites in the United States …

2022年12月15日 · HEK cells transfected with human CD33 (CD33-3 or CD33m) or mouse (CD33m) isoforms were fixed, permeabilized, then incubated with 24F3 followed by a …

2025年2月22日 · Whitney is a volunteer in the Dominantly Inherited Alzheimer Network (DIAN). Genetic analysis and extensive clinical profiling point toward some possible protective factors, …

2019年7月11日 · CD33-deficient 5xFAD mice had markedly fewer plaques and lower levels of insoluble Aβ42 than 5xFAD controls, but knocking out TREM2 eliminated this protective effect. …

Blots probed with anti-myc antibody 9E10. All three CD33 isoforms are captured by 2C11. *, non-specific bands. [Courtesy of Christian Haass' laboratory.] Generation and epitope mapping. …