CD4+ T cells produce IFN-I to license cDC1s for induction of …
2024年2月21日 · Activated CD4 + T cells produce IFNβ via the STING pathway, which promotes MHC-I antigen (cross-)presentation by cDC1s and thereby improves their ability to induce CTL …
Long-Lived CD4+IFN-γ+ T Cells rather than Short-Lived CD4+IFN …
In this study, utilizing a novel tractable IFN-γ and IL-10 dual reporter system, we have shown that IL-10–producing Ag-experienced CD4 + T cells generated during the early phases of primary …
IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the ... - Nature
2022年4月25日 · Here, we report that IFN-γ + CD4 + T cells display direct ex vivo cytolytic activity and demonstrate that genetic ablation of IFN-γ or its blockade inhibits CD4 + CTL generation …
Gamma interferon responses of CD4 and CD8 T-cell subsets are ... - PubMed
Gamma interferon (IFN-gamma) is a key cytokine in host defense against intracellular mycobacterial infection. It has been believed that both CD4 and CD8 T cells are the primary …
CD4 + T cells produce IFN-I to license cDC1s for induction of
Activated CD4 + T cells produce IFNβ via the STING pathway, which promotes MHC-I antigen (cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer …
Responsive tumors have an inflammatory and highly immune infiltrated pre-treatment tumor microenvironment characterized by the enrichment of pathways associated with CD4+T cells, …
IFN-γ mediates CD4 + T-cell loss and impairs secondary ... - Nature
2007年3月4日 · We observed significant increases of CD4 + T cells in the spleens of Ifngr −/− mice after treatment, demonstrating that the host's ability to respond to IFN-γ is necessary for …
IFN-γ from CD4 T cells is essential for host survival and enhances …
CD4 T cells are a significant source of IFN-γ during acute infection in mice and are required for control of bacterial growth and host survival. However, several other types of cells can and do …
Human CD4+ memory phenotype T cells use mitochondrial …
T cell production of the cytokine interferon (IFN)-γ plays a key role in both tumor control and graft-mediated pathology following hematopoietic transplantation. 1 CD4 + T cells become T H1 …
CD4 + T cells drive an inflammatory, TNF-α/IFN-rich tumor ...
2022年12月27日 · They find that a CD4 T cell associated inflammatory IFN/TNF-α gene signature is associated with response in a murine mesothelioma model and patients with breast cancer. …