Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells. Many of these cells recognize the non-polymorphic CD1d …

Natural killer T (NKT) cells are a developmentally and functionally distinct lineage of T cells restricted by CD1d–lipid antigen complexes. These cells branch from conventional...

2020年6月24日 · Key subsets of unconventional T cells include natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells and γδ T cells; collectively, these make up ~10% …

Human iNKT cells can be CD4 +, CD8 + double-negative (CD4 − CD8 −), whereas NKT cells in mice are either CD4 + or CD4 − CD8 − [23,24,25]. This is due to mouse iNKT cells expressing …

2003年8月1日 · CD1d-restricted NKT cells include CD4 + and CD4 − CD8 − double-negative (DN) subsets and express a heavily biased TCR repertoire, with the majority expressing an invariant …

Our findings provide new insights into the early development of NKT cells prior to surface expression of the invariant Valpha14 antigen receptor and suggest the possible alternative …

Although natural killer T cells (NKT cells) are thought to be generated from CD4+CD8+ (DP) thymocytes, the developmental origin of CD4−CD8− (DN) NKT cells has remained unclear. In …

2010年2月7日 · The human CD4 + NKT subset produces both T helper type 1 (T H 1) and T H 2 cytokines, whereas CD4 − NKT cells produce mainly T H 1 cytokines 67,68.

Of relevance, NKT cells do indeed include a subset of CD4-NK1.1-IL-17-producing cells (Coquet et al., 2008). Moreover, NKT cells have been implicated in SLE pathogenesis where the …

2007年7月1日 · Using blocking reagents neutralizing CD4 binding, experimental systems where MHC class II molecules are absent and recombinant alpha-GalCer/CD1d complexes, we show …