CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells [5] and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen …

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is …

Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on T H cells to CD40 …

CD40L, also known as gp39, CD154 and TNFSF5, is a type II membrane glycoprotein with a 22 aa cytoplasmic tail a 24 aa transmembrane domain and a 215 aa extracellular domain in …

CD40 ligand (CD40L) is a 261-amino-acid membrane glycoprotein expressed on activated CD4 lymphocytes. Expression occurs shortly after T cell activation. The natural ligand for CD40L is …

CD40 binds its ligand CD40L, which is transiently expressed on T cells and other non-immune cells under inflammatory conditions. A wide spectrum of molecular and cellular processes is …

CD40L is a member of the tumor necrosis factor (TNF) family of cell surface interaction molecules. It is a 261-amino-acid type II membrane glycoprotein, and its expression is mainly …

2021年3月1日 · The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form …

The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate …

2002年8月20日 · CD40L is a trimeric, transmembrane protein of the tumor necrosis factor family that was originally identified on cells of the immune system (activated CD4+ cells, mast cells, …

The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a soluble …

2020年11月12日 · In this review, we will discuss the setbacks encountered as well as new avenues discovered on the path to a different, inflammation-centered approach for the …

The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T …

2019年3月18日 · CD40 ligand (CD40L) is a type II transmembrane protein that belongs to the tumor necrosis factor gene superfamily and is mainly expressed on activated T cells and …

The CD40–CD40 ligand (CD40L) dyad represents a scientific and clinical field that has raised many controversies in the past and cannot be clearly defined as being an either beneficial or …

2000年2月1日 · CD40L triggered increased p53 and p21 mRNA (Figures 3 A, 3 C) and protein (Figures 3 B, 3 D) expression in both MM cell lines when cultured at permissive, but not at …

In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC) - T cell and DC-B cell cross-talk. In addition, we examine differences and …

2020年9月8日 · CD4 + T cells express CD40 ligand (CD40L). CD40L induces endothelial cells, vascular smooth muscle cells, and macrophages to express procoagulant factors [ 47 , 48 ]. …

Glial cells, neurons and mast cells communicate with each other through various signaling pathways, including CD40L, CD40, toll-like receptor 2 (TLR2), TLR4, PAR-2, chemokine …

While the two major T cell subsets, CD4 + helper and CD8 + cytotoxic, were differentiated from control Bcl11b +/+ progenitors, Bcl11b m/m progenitors gave rise to predominantly CD4 + T …