
CD49d promotes disease progression in chronic lymphocytic leukemia…
2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression.
CD49d promotes disease progression in chronic lymphocytic ... - PubMed
2020年4月9日 · CD49d is a remarkable prognostic biomarker of chronic lymphocytic leukemia (CLL). The cutoff value for the extensively validated 30% of positive CLL cells is able to separate CLL patients into 2 subgroups with different prognoses, but it does not consider the pattern of CD49d expression.
CD49d - an overview | ScienceDirect Topics
CD49d is a surface subunit of the integrin heterodimer that is involved in promoting survival of the CLL cells through microenvironment derived growth signals. CD49d can be used as a reliable predictive marker of aggressive disease course and inferior survival is associated with ≥30% cells expressing CD49d by flow cytometry.
CD49d Is the Strongest Flow Cytometry–Based Predictor of Overall ...
2014年2月10日 · In this analysis of approximately 3,000 patients, CD49d emerged as the strongest flow cytometry–based predictor of OS and TFS in CLL.
CD49d expression is an independent predictor of overall survival …
CD49d (integrin alpha 4) plays a critical role in leucocyte trafficking, activation, and survival, and also facilitates interactions between leucocytes and stromal cells found in the marrow or germinal center of lymphoid follicles via VCAM-1 and fibronectin (Rose et al, 2002).
CD49d in chronic lymphocytic leukemia: a molecule with multiple ...
2024年1月1日 · Functionally, CD49d is the α4 chain of the α4/β1 complex (CD49d/CD29) composing the very late antigen-4 (VLA-4) integrin. VLA-4 operates as a cell-cell and cell-matrix receptor by interacting with its specific ligands: VCAM-1 involved in cell-cell interactions, and FN and EMILIN1 both involved in cell-matrix interactions.
The pathogenic relevance of the prognostic markers CD38 and CD49d …
A more recently discovered marker is CD49d, the alpha4 subunit of the VLA-4 integrin (alpha4beta1). High CD49d expression predicts reduced overall survival and time to first treatment in CLL patients [10, 11].
CD49d Expression Identifies a Biologically Distinct Subtype of …
2022年11月15日 · CD49d, the alpha chain of the CD49d/CD29 integrin very late antigen-4 (VLA-4), is a key mediator in CLL microenvironmental interactions. High CD49d expression has been associated with inferior response to ibrutinib (Tissino, 2018).
The CD49d/CD29 complex is physically and functionally ... - Nature
2012年1月6日 · Here, we demonstrate a constitutive physical association between the CD49d/CD29 integrin complex and CD38 in primary CLL cells and B-cell lines by (i) cocapping, (ii) coimmunoprecipitation and...
Functional and clinical relevance of VLA-4 (CD49d/CD29) in …
CD49d, the α chain of the CD49d/CD29 integrin heterodimer very late antigen 4 (VLA-4), expressed in ∼40% of chronic lymphocytic leukemia (CLL) cases, has emerged as one of the most relevant biological predictors of overall survival (OS) and progression-free survival (PFS) in CLL (Gattei et al., 2008; Shanafelt et al., 2008; Bulian et al., 2014).
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