Lack of involvement of CD63 and CD9 tetraspanins in the ... - Nature
2023年5月17日 · CD63 and CD9 have been suspected to regulate the EV uptake and delivery process. Here we used two independent assays and different cell models (HeLa, MDA-MB …
CD63 CRISPR knockout results in decreased EV secretion. (a) …
To confirm the role of CD63 in exosome biogenesis, we designed a stable CD63 knockout cell line using the CRISPR/Cas9 system. Endogenous CD63 pro- tein was effectively eliminated in …
CD63 sorts cholesterol into endosomes for storage and ... - Nature
2024年6月17日 · Here we report that a key component of small extracellular vesicles, the tetraspanin CD63, sorts cholesterol to ILVs, generating a pool that can be mobilized by the …
CD63 (CD63)靶点介绍及实验小贴士| Abcam中文官网
跨膜四超家族蛋白cd63被认为是一个调控细胞外囊泡产生和胞内体货物分选的关键因子。 cd63基因定位于人染色体12q13上，编码含237氨基酸的蛋白。 cd63蛋白结构包括n端和c端胞内结构 …
Cd63-KO - 南模生物
敲除Cd63基因的exon 3-8 区域，获得Cd63基因敲除小鼠模型。 应用领域 ：免疫相关 *使用本品系发表的文献需注明: Cd63-KO mice (Cat. NO. NM-KO-190044) were purchased from …
JEV：差异蛋白质组学发现CD9/CD81/CD63将蛋白质分选到EVs中 …
2023年8月15日 · CD63 KO小鼠由于pmel转运和加工的改变而具有受损的色素沉着能力，pmel是参与黑色素生成的分子，以及肾功能异常，包括多尿并伴有尿渗透压下降以及有机阳离子转运 …
Differential proteomics argues against a general role for CD9, …
Three studies investigated the impact of CD63 KO, CD9 KO or CD9 silencing on the protein composition of EVs secreted by different cell lines (Brzozowski et al., 2018; Hurwitz et al., …
CD63：早期诊断和精准治疗的冉冉新星 - 知乎 - 知乎专栏
CD63是 外泌体 特异性标志蛋白，为新型药物递送及靶向外泌体提供契机，还可作为肿瘤的潜在标志物（如 卵巢癌 、 肺癌 等）。 研究人员利用 重组CD63蛋白 开发多种适配体，用于非侵入 …
CD63 acts as a functional marker in maintaining hematopoietic …
2021年8月6日 · In this study, we identify tetraspanin CD63 as a novel functional marker of HSCs in mice. We show that CD63 is unevenly expressed on the cell surface in HSC populations.
Extracellular Vesicle Trafficking Regulates Hematopoietic Stem and ...
2023年11月2日 · To segregate metabolic regulation of HSPCs by sphingolipids from their role in EV formation and secretion, we began to systematically modulate and compare several core …