CD63 is a good marker for flow cytometric quantification of in vitro activated basophils for diagnosis of IgE-mediated allergy. The test is commonly designated as basophil activation test (BAT).

CD63是 外泌体 特异性标志蛋白，为新型药物递送及靶向外泌体提供契机，还可作为肿瘤的潜在标志物（如 卵巢癌 、 肺癌 等）。 研究人员利用 重组CD63蛋白 开发多种适配体，用于非侵入型外泌体的检测。 CD63靶点的多面性为治疗、诊断和生物医学研究带来新希望。 CD63生理学和病理学意义. CD63参与多种细胞进程，在晚期内体和多泡体的细胞蛋白分选中发挥关键作用，促进外泌体形成。 通过靶向CD63介导外泌体药物的精准递送有助于实现靶向治疗。 在免疫反应中，表 …

溶酶体靶向基序进行突变为cd63-ya，cd63-wt-egfp或cd63-ya-egfp rush质粒转染的hela细胞；结果显示，在稳定状态下，与cd63-wt相反，cd63-ya主要位于细胞外围和一些小的细胞内区室中。

CD63可以与多种细胞表面蛋白和细胞内信号转导分子相互作用，介导运动、黏附和信号转导等一系列生物过程。 可在血小板中检测到 (在蛋白质水平)。 发育不良痣，放射状生长期原发黑色素瘤，造血细胞，组织巨噬细胞。 细胞膜，胞内体，溶酶体. 图二：CD63靶点ICC实验结果图，Anti-CD63产品 (ab217345)。 绿色：CD63，红色：alpha Tubulin，蓝色：DAPI。 人（P08962）：异构体1-3：17.2-25.6 kDa（预测）； 小鼠（P41731）：25.7 kDa（预测） 大 …

2024年6月7日 · Recognizing CD63 + TAMs as crucial regulators of HCC progression offer opportunities for therapeutic intervention. Targeting CD63 + TAMs could disrupt the pre-tumorigenic communication between TAMs and HCC cells, leading to the development of novel immunotherapeutic strategies.

2020年11月27日 · CD63, a member of transmembrane-4-superfamily of tetraspanin proteins and a highly N-glycosylated type III lysosomal membrane protein, is known to regulate malignancy of various types of cancers such as melanoma and breast cancer and serves as a potential marker for cancer detection.

CD63, a member of the tetraspanin membrane protein family, plays a pivotal role in cell growth, motility, signal transduction, host-pathogen interactions and cancer. In this work, the cDNA encoding CD63 homologue (TmCD63) was cloned from larvae of a …

1996年5月6日 · CD63 belongs to the Transmembrane 4 superfamily (TM4SF) of membrane proteins whose functions are largely unknown. Previous results have suggested that CD63 may play an important role in the regulation of melanoma progression.

2021年8月27日 · This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly.

本文综述了 TIMP1、CD63 和 β1-整联蛋白各自执行的特征和功能、TIMP-1/CD63/β1-整联蛋白复合物在生理背景和癌症中的作用，以及其涉及的调节机制。 集会。 Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-established function of inhibiting the proteolytic activity of matrix metalloproteases.