
CD63 - Wikipedia
CD63 is a good marker for flow cytometric quantification of in vitro activated basophils for diagnosis of IgE-mediated allergy. The test is commonly designated as basophil activation test (BAT).
CD63:早期诊断和精准治疗的冉冉新星 - 知乎 - 知乎专栏
CD63是 外泌体 特异性标志蛋白,为新型药物递送及靶向外泌体提供契机,还可作为肿瘤的潜在标志物(如 卵巢癌 、 肺癌 等)。 研究人员利用 重组CD63蛋白 开发多种适配体,用于非侵入型外泌体的检测。 CD63靶点的多面性为治疗、诊断和生物医学研究带来新希望。 CD63生理学和病理学意义. CD63参与多种细胞进程,在晚期内体和多泡体的细胞蛋白分选中发挥关键作用,促进外泌体形成。 通过靶向CD63介导外泌体药物的精准递送有助于实现靶向治疗。 在免疫反应中,表 …
文献解读 | 原来CD63才是外泌体特异性标志性蛋白,而CD9 …
溶酶体靶向基序进行突变为cd63-ya,cd63-wt-egfp或cd63-ya-egfp rush质粒转染的hela细胞;结果显示,在稳定状态下,与cd63-wt相反,cd63-ya主要位于细胞外围和一些小的细胞内区室中。
CD63 (CD63)靶点介绍及实验小贴士| Abcam中文官网
CD63可以与多种细胞表面蛋白和细胞内信号转导分子相互作用,介导运动、黏附和信号转导等一系列生物过程。 可在血小板中检测到 (在蛋白质水平)。 发育不良痣,放射状生长期原发黑色素瘤,造血细胞,组织巨噬细胞。 细胞膜,胞内体,溶酶体. 图二:CD63靶点ICC实验结果图,Anti-CD63产品 (ab217345)。 绿色:CD63,红色:alpha Tubulin,蓝色:DAPI。 人(P08962):异构体1-3:17.2-25.6 kDa(预测); 小鼠(P41731):25.7 kDa(预测) 大 …
CD63 + tumor-associated macrophages drive the progression of ...
2024年6月7日 · Recognizing CD63 + TAMs as crucial regulators of HCC progression offer opportunities for therapeutic intervention. Targeting CD63 + TAMs could disrupt the pre-tumorigenic communication between TAMs and HCC cells, leading to the development of novel immunotherapeutic strategies.
Development of a CD63 Aptamer for Efficient Cancer ... - PubMed
2020年11月27日 · CD63, a member of transmembrane-4-superfamily of tetraspanin proteins and a highly N-glycosylated type III lysosomal membrane protein, is known to regulate malignancy of various types of cancers such as melanoma and breast cancer and serves as a potential marker for cancer detection.
Molecular Cloning, Sequence Characterization and Expression …
CD63, a member of the tetraspanin membrane protein family, plays a pivotal role in cell growth, motility, signal transduction, host-pathogen interactions and cancer. In this work, the cDNA encoding CD63 homologue (TmCD63) was cloned from larvae of a …
CD63 Associates with Transmembrane 4 Superfamily
1996年5月6日 · CD63 belongs to the Transmembrane 4 superfamily (TM4SF) of membrane proteins whose functions are largely unknown. Previous results have suggested that CD63 may play an important role in the regulation of melanoma progression.
Characteristics of TIMP1, CD63, and β1-Integrin and the …
2021年8月27日 · This article reviewed the characteristics and functions performed individually by TIMP1, CD63, and β1-integrin, the roles of the TIMP-1/CD63/β1-integrin complex, both in a physiological context and in cancer, and the regulatory mechanisms involved in its assembly.
<br>TIMP1、CD63 和 β1-整合素的特征及其相互作用对癌症的功 …
本文综述了 TIMP1、CD63 和 β1-整联蛋白各自执行的特征和功能、TIMP-1/CD63/β1-整联蛋白复合物在生理背景和癌症中的作用,以及其涉及的调节机制。 集会。 Tissue Inhibitor of Metalloproteases 1, also known as TIMP-1, is named for its well-established function of inhibiting the proteolytic activity of matrix metalloproteases.