Resting naive CD8 + T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection.

2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...

2011年7月15日 · In this article, we report on the ability of seven monoclonal anti-human CD8 Abs to activate six human CD8 + T cell clones with a total of five different specificities. Six of seven anti-human CD8 Abs tested did not activate CD8 + T cells. In contrast, one anti-human CD8 Ab, OKT8, induced effector function in all CD8 + T cells examined.

2022年10月3日 · CD8 + T cells have direct cytotoxic effect towards target cells and play a crucial role in anti-tumour therapy. When naïve CD8 + T cells go through the process of differentiation, mature effector CD8 + T cells can be formed, which can effectively clear antigens.

2023年8月3日 · Here, we report that CD8 + T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression. This capacity proves to be dependent instead on interactions between T...

2019年2月8日 · We show here that two commonly used mAbs, against either the CD8α or CD8β subunit, can differentially affect cellular metabolism. Further, in vivo treatment leaves behind a population of CD8+ T cells with different phenotypic and functional attributes relative to each other or control CD8+ T cells.

2009年6月1日 · Our data indicate that chronic Ag stimulation alone is sufficient to induce CD8 + T cell exhaustion, as shown by the failure of virus-specific CD8 + T cells to re-expand or produce IFN-γ upon viral rechallenge.

Thus, the coexpression of CD8 alpha and CD8 beta in conjunction with the TCR/CD3 complex appears to characterize MHC restricted cells while the expression of CD8 alpha alone is associated with non-MHC-restricted cytotoxicity.

The mouse CD8 (+) DCs are non-migrating resident DCs derived from a precursor, distinct from monocytes, that continuously seeds the lymphoid organs from bone marrow. They differ in several key functions from their CD8 (-) DC neighbors.

Solid tumors and lymphomas are infiltrated by a majority of TCRVγnon9 γδ T cells which are quantitatively correlated and remarkably aligned with T CD8 for differentiation, exhaustion, gene expression profile, and response to immune checkpoint therapy. This cancer-wide association is critical for developing cancer immunotherapies.