cd3+淋巴细胞指的是全t淋巴细胞 包含cd3+cd4+细胞(辅助/话导t淋巴细胞)、cd3+cd8+细胞(抑制 细胞毒T淋巴细胞)CD4+CD45RA+/CD4+CD45RA+62L+(CD4+T细胞纯真亚群)和 CD4+CD45RA-/CD4+CD45RO+(记忆亚群)、CD28+(功能亚群)、CD38+、HLA-DR+(激活亚群)、CD95+(凋亡亚 …

本文是针对论文《CD8+ T细胞亚群在抗肿瘤免疫中的作用（The Roles of CD8+ T Cell Subsets in Antitumor Immunity）》的一篇解析，该论文于2020年7月发表于《细胞生物学的发展趋势（Trends in Cell Biology）》。 综述背景： 相关研究表明CD8+T细胞在抗肿瘤治疗过程中起到至关重要的作用，与CD4+T细胞相似， CD8+T细胞也有多个亚型，不同的亚型它的产生过程和功能是有所区别的，比如，并不是所有亚群都具有细胞毒性功能并产生 IFN-γ。 所以深入了解不 …

2023年10月23日 · CD8 + T-cells are critical for clearing intracellular pathogens and tumors. The efficacy of CD8 + T-cell responses relies on the recruitment of different clones, the formation of a strong...

2022年4月12日 · 作为典型的细胞毒性 CD8 + T 细胞，高表达穿孔素、颗粒酶 B、IFN-γ 和肿瘤坏死因子 (TNF-α) ，与其他 Tc 谱系相关的细胞因子的低表达（联想到张泽民老师的分类注释 软件的依据）。 Tc1s 的诱导由细胞因子 IL-12 介导，该细胞因子通常由抗原呈递细胞 (APC)，包括巨噬细胞和树突状细胞，在暴露于病原体衍生的成熟刺激时产生（？ 白细胞介素这样用）。 除了它们的细胞因子谱不同，Tc1 细胞还可以通过它们在细胞表面上升高的 IL18R 表达与其他 Tc 亚群 …

Based on recent clinical trial results, therapeutic peptide-based cancer vaccines using emulsions in adjuvant Montanide ISA-51 can elicit robust antitumor immune responses, provided that sufficient tumor-specific CD4 + T cell help is given in addition to CD8 + T cell epitopes.

2014年2月26日 · Since CD69 has been identified as the earliest T cell activation marker and CD25, the high-affinity interleukin-2 (IL-2) receptor α chain, is rapidly up regulated by antigen-specific CD8 + T cells after T cell activation, these results demonstrate that Q11-OVA nanofibers elicit higher frequencies of CD8 + T cells with enhanced activation ...

Deoxycytidyl-deoxyguanosin oligodeoxynucleotides (CpG ODNs) trigger Toll-like receptor 9, resulting in dendritic cell maturation that can enhance immunogenicity of peptide-based vaccines in mice. We tested whether a synthetic ODN, CpG 7909, could improve human tumor antigen-specific CD8+ T cell responses.

After 4 vaccinations with CpG 7909, Melan-A peptide, and IFA, all 8 patients exhibited increased frequencies of Melan-A–specific CD8 + T cells (0.07–3.00%), resulting in significantly (P < 0.01) higher percentages than before vaccination (Figure 1, A and B).

Oleic acid used in the surfactant was purified from a vegetable source (olives, IFA-VG) rather than an animal source (beef tallow, IFA-AN). To provide an insight into the adjuvant properties of the new formulation, we reviewed T-cell responses, by enzyme-linked immunospot assay, to multipeptide vaccines in 2 sequential clinical trials that ...

2007年10月15日 · Our data clearly show why priming of CTL with minimal peptide epitopes in IFA is suboptimal, and demonstrate that the use of longer versions of these CTL peptide epitopes ensures the induction of sustained effector CD8(+) T cell reactivity in vivo.