2022年8月30日 · Tregs是免疫抑制性T细胞，在预防自身免疫和病原体诱导的免疫病理学方面发挥关键作用，从而维持免疫稳态和自我耐受。 具有抑制活性的 CD8+ T 细胞在20世纪70年代就有人研究，然而，由于缺乏特异性标志物和基因表达调节分子，导致该研究方向一度被放弃。

研究表明，Treg对效应记忆CD8 T细胞具有明显抑制作用，并能揭示Treg在病毒感染中的表型分化。 scSPOT具有可扩展性和广泛适用性，可用于Treg免疫生物学研究及药物筛选。

2021年8月17日 · CD8 + Tregs perform their regulatory function by killing antigen activated CD4 + T cells and T FH cells. The main cytotoxic molecule shown to be important for CD8 + Treg function is perforin. CD8 + Treg from Prf1-/-mice were not able to suppress antigen-activated T FH cells in Rag2-/-mice .

2023年11月1日 · The diverse subsets of CD8 T cells, including Tc1 cells, Tc2 cells, Tc9 cells, Tc17 cells, Tc22 cells, Tfcs, and suppressive CD8 Tregs, have emerged as critical players in immune responses...

We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of individual CD8 + T-cell subsets with proposed regulatory capacity separately.

We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8 + Tregs by focusing on the characterization of individual CD8 + T-cell subsets with proposed regulatory capacity separately.

CD8 + Treg are loosely defined as a heterogenous population of CD8 + lymphocytes that can express several Treg associated surface markers and have immunosuppressive capacity, thus defining them as a Treg subset (131–133).

2018年3月5日 · CD8 + Treg cells may play a role in promoting imbalance of the immune system in tumor growth. These immune-tolerance mechanisms may also be exploited by cancer cells to achieve immune escape,...

In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss the biology, development and induction of CD8 + Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future ...

In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8 + and CD4 + Tregs, and we will discuss the biology, development and induction of CD8 + Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically...