2011年9月13日 · Treatment of Cd81-deficient HSCs with an Akt inhibitor, perifosine, which bypasses the requirement for CD81 in this process, rescues the delay defect of Cd81-deficient HSCs. Together, our data demonstrate that CD81 is critical to maintaining the functional integrity of HSCs during regeneration, and it is acting through Akt to influence its ...

CD81 and Claudin-1 —The observation that the AKT activation was detected as early as 15 min and peaked by 30 min after HCV infection indicated the involvement of an early HCV infection event ...

CD81 overexpression increased the number of cells with a migratory phenotype, in a potentially phosphatidylinositol 3 kinase (PI3K)-Ak strain transforming (AKT) mediated manner. Indeed, CD81 also co-localized with AKT, a CD81-interactor and actin remodeling agent, at the inner leaflet of the plasma membrane.

2023年12月22日 · 进一步研究揭示，cd81通过akt依赖的sp1激活信号通路诱导mt1-mmp的表达，进而刺激黑色素瘤细胞的运动，增加黑色素瘤的侵袭和转移 [23-24] 。此外，cd81的缺失也严重损害了调节性t细胞和髓源性抑制细胞的功能 [25] 。

Here, we show that lack of CD81 leads to loss of HSC self-renewal, and the clustering of CD81 on HSC membrane results in deactivation of Akt, which subsequently leads to nuclear translocation of FoxO1a. Thus, CD81 functions as part of a previously undefined mechanism that prohibits excessive proliferation of HSCs exposed to environmental stress.

2021年11月25日 · CD81 membrane protein promotes melanoma cell motility by inducing metalloprotease MT1-MMP expression through the Akt-dependent Sp1 activation signaling pathway 8.

2021年5月12日 · CD81 exerts a wide range of regulatory effects on immune cells. In B cells, CD81 facilitates the assembly of CD19-CR2/CD21 and B-cell receptor complexes at tetraspanin-enriched signaling...

2008年11月16日 · In addition, clustering of CD81 on the HSC cell membrane using a monoclonal antibody rapidly induced a quiescent phenotype. This was found to be associated with an altered phosphorylation level of AKT, an inhibitor of the transcription factor FOXO1a and FOXO3a, which have been reported to be essential for HSC self-renewal through suppressing ...

CD81, also called TAPA-1, is a type III transmembrane protein that is broadly expressed on cells of hematopoietic, neuroectodermal and mesenchymal origin. CD81 is believed to be involved in both cell growth and signal trans-duction. It can be present as a …

2014年5月5日 · Results: CD81-Akt signaling induces Sp1-mediated MT1-MMP expression, which enhances melanoma cell motility and invasiveness. Conclusion: CD81 functions as an inducer of MT1-MMP that plays a role in melanoma invasive processes.