四次跨膜蛋白CD81：丙型肝炎病毒（HCV）关键受体，外泌体重 …
2023年12月22日 · CD81（又名Tetraspanin-Associated Protein 1，TAPA-1）是首个被认定的HCV感染靶细胞的受体分子，最初是在筛选能抑制B淋巴细胞瘤增殖的单克隆抗体的过程中被 …
CD81 and Hepatitis C Virus (HCV) Infection - PMC
Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In this review, we detail the current knowledge …
Hepatitis C virus enters liver cells using the CD81 receptor ... - PLOS
2018年7月19日 · Our findings reveal a comprehensive CD81 network in human liver cells and show that HCV and Plasmodium highjack selective CD81 interactions, including CAPN5 and …
Structural insights into hepatitis C virus receptor binding ... - Nature
2021年9月15日 · Crystal structures of the hepatitis C virus (HCV) glycoprotein E2 in complex with CD81 reveal the conformational changes that occur in E2 after binding of CD81 and the …
CD81 antigen (CD81)靶点介绍及实验小贴士| Abcam中文官网
CD81是四跨膜蛋白超家族（TM4SF）成员之一，可以与其他四跨膜蛋白、整合素、辅助受体、MHC I类或II类分子形成复合物，影响B、T细胞的粘附、形态、激活、增殖和分化。
CD81 suppresses NF-κB signaling and is downregulated in …
2024年1月31日 · CD81 was downregulated at the mRNA level in hepatoma cells that replicate HCV. Kinetics of HCV expression were increased in CD81-knockout cells and accompanied by …
CD81-Receptor Associations — Impact for Hepatitis C Virus Entry …
CD81 also plays a crucial role in pathogen entry into host cells, including hepatitis C virus (HCV) entry into hepatocytes. HCV is a major cause of liver cirrhosis and hepatocellular carcinoma.
Hepatitis C virus entry: potential receptors and their biological ...
Several cellular molecules have been identified as putative receptors for Hepatitis C virus (HCV): CD81 tetraspanin, scavenger receptor class B type I (SR-BI), mannose-binding lectins DC …
CD81+ Exosomes Play a Pivotal Role in the Establishment of ... - PubMed
CD81 serves as an immune modulator, playing its role in tumor growth and metastasis of hepatitis C virus (HCV)-mediated hepatocellular carcinoma (HCC). CD81 serves as a coreceptor of viral …
诺奖得主利用定量蛋白组学确定丙型肝炎病毒（HCV）的进入机制
2020年10月13日 · 丙型肝炎病毒（HCV）通过多步机制进入人类肝细胞，其中包括宿主蛋白以及其他病毒受体CD81。 作者利用定量蛋白质组学，以识别HCV触发的CD81相互作用，并找到26 …