2022年10月1日 · In this study, we provide the first indication that accumbal CD81 expression is essential for voluntary ethanol intake and preference in mice, as we show that shRNA-expressing lentiviral-mediated knockdown of CD81 mRNA in the Nacc impairs ethanol intake.

2024年11月19日 · We found that the human melanoma cell line SK-MEL-28 in which SNCA is knocked out (SNCA -KO) has low levels of tetraspanin CD81, which is a cell-surface protein that promotes invasion, migration, and immune suppression.

2020年7月1日 · CD81 forms a complex with αV/β1 and αV/β5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation.

2025年1月25日 · For example, Cd81 preserves metabolic health in adipocytes and counteracts the effects of overnutrition by high fat feeding via anti-inflammatory signaling. 40 By contrast, Cd9 marks a population of pro-inflammatory cells in the brain 41 and adipose tissue. 42 Exercise can increase the circulating abundance of both Cd9 and Cd81 in EVs, 43, 44 ...

Indeed the targeted disruption of CD81, with the resultant decrease in CD81 mRNA in the Nacc, converted ethanol-"preferring" mice into ethanol "non-preferring" mice. Collectively, these findings demonstrate that future CD81-targeted pharmacotherapies may be beneficial for the treatment of anxiety and alcoholism.

We found that in the absence of CD81, in thymocytes from knockout mice, TCR engagement resulted in stronger signals. These results were recapitulated in T cell lines that express low levels of CD81 through shRNA mediated silencing. Increased signaling did not result from alterations in the levels of TCR on the surface of T lymphocytes.

2011年11月18日 · Expression of CD81 in MM-PC is an independent prognostic factor for patients with symptomatic MM and a marker for risk of progression in SMM. Blockage of CD81 with anti-CD81 antibodies does not show significant anti-myeloma activity; therefore, the precise mechanism of CD81 activation of MM-PC deserves further investigations.

2019年9月7日 · CD81 is a 26 kDa member of the tetraspanin family and is expressed in various types of cells. Experiments using CD81-knockout mice have shown that CD81 is not essential for the development of T and B lymphocytes, but may play an important role in the proliferation and proper immune response of B cells [7, 8].

2024年3月7日 · Bulk RNA sequencing results after sorting CD81 high CD82 high and CD81 low CD82 low T cells consistently supported the roles of CD81 and CD82. Experiments with overexpressed CD81 and CD82 showed increased cytotoxicity against target cells.

Description: Homo sapiens CD81 molecule (CD81), transcript variant 2, mRNA. (from RefSeq NM_001297649) RefSeq Summary (NM_001297649): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of ...