Cluster of differentiation 86 (CD86), also known as B7-2, is a molecule expressed on antigen-presenting cells that provides the costimulatory signals required for T cell activation and survival. CD86 binds to two ligands on the surface of T cells: ...

2024年12月24日 · CD86 (CD86 Molecule) is a Protein Coding gene. Diseases associated with CD86 include Plague and Cowpox. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and coreceptor activity.

CD86 refers to a 70-kDa glycoprotein consisting of 329 amino acids, a transmembrane region, and a longer cytoplasmic domain. It is expressed on various immune cells such as interdigitating DCs, Langerhans cells, B cells, and macrophages.

2022年8月23日 · These observations provide a rationale for two distinct ligands and show that defects in CTLA-4-mediated transendocytosis of CD86 are associated with autoimmunity.

CD86 is a glycosylated protein of approximately 70 KDa, composed of 329 amino acids (about 37 KDa), a single transmembrane domain, and a cytoplasmic domain. CD86 is expressed on antigen-presenting cells and serves as a ligand for two proteins on T cells, CD28 and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4).

Dendritic cells (DCs) require costimulatory molecules such as CD86 to efficiently activate T cells for the induction of adaptive immunity. DCs maintain minimal levels of CD86 expression at rest, but upregulate levels upon LPS stimulation. ...

2012年5月24日 · CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.

2025年2月8日 · CD86 was found to be concentrated within the cytoplasmic vesicles of macrophages and dendritic cells. a soluble form of CD86 encoded by an alternatively spliced transcript is present at elevated levels in blood in some leukaemia patients

The protein CD86 is a molecule expressed on antigen-presenting cells that provide costimulatory signals necessary for T cell activation and survival. It is the ligand for two proteins at the cell surface of T cells, the CD28 costimulatory receptor and the CTLA-4 (cytotoxic T-lymphocyte-associated protein 4).

CD86 is a ligand of CD28, a potent costimulatory receptor required for the optimal activation of CD4 + T cells. Moreover, we have shown that ligation of the activating NK receptors (e.g., CD16 and KIR), which signal through the ITAM-bearing DAP12 or CD3ζ/FcɛRIγ adapter proteins, induce expression of OX40 ligand (OX40L) on innate cytokine ...