2021年7月22日 · Having a CDH1 mutation means that you are at high risk for developing a very aggressive form of stomach cancer called hereditary diffuse gastric cancer (HDGC). The CDH1 mutation also puts women at risk for a certain form of breast cancer called lobular breast cancer.

Cadherin-1 is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail.

The CDH1 gene provides instructions for making a protein called epithelial cadherin or E-cadherin. This protein is found within the membrane that surrounds epithelial cells, which are the cells that line the surfaces and cavities of the body, such as the inside of the eyelids and mouth.

2024年12月24日 · CDH1 (Cadherin 1) is a Protein Coding gene. Diseases associated with CDH1 include Diffuse Gastric And Lobular Breast Cancer Syndrome and Blepharocheilodontic Syndrome 1. Among its related pathways are Cell junction organization and Uptake and actions of bacterial toxins.

We review current perspectives in CDH1 genetics with molecular mechanisms and also discuss management strategies for this aggressive form of gastric cancer.

Carrying a mutation in the CDH1 gene raises the risk of diffuse gastric cancer as much as 70% for men and 56% for women, compared to a <1% chance in people without a CDH1 mutation. What is the CDH1 gene and how does this gene play a role …

CDH1 gene mutations are rare and hereditary (inherited by a parent). If you have a mutation in your CDH1 gene, you may also have a condition known as Hereditary Diffuse Gastric Cancer (HDGC) syndrome, which dramatically increases your lifetime risk for developing diffuse stomach (gastric) cancer and lobular breast cancer.

CDH1 pathogenic variants confer a markedly elevated lifetime risk of developing diffuse gastric cancer (DGC) and lobular breast cancer (LBC). The aim of this study was to evaluate the prevalence and clinical impact of CDH1 pathogenic variants in the unselected and ancestrally diverse Bio Me Biobank.

Hazard Ratio and Cumulative Risk Estimates of Advanced Gastric and Breast Cancer for CDH1 P/LP Variant Carriers. Supplement 1. Supplement 2. Guilford PJ, Hopkins JB, Grady WM, et al. E-cadherin germline mutations define an inherited …

2025年3月8日 · CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018] Broad expression in thyroid (RPKM 81.8), colon (RPKM 70.0) and 17 other tissues See more. Go to reference sequence details.