CDK12 Gene - GeneCards | CDK12 Protein | CDK12 Antibody
2024年12月24日 · CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Prostate Cancer, Hereditary, 1 and Hereditary Breast Ovarian …
学术前沿 | CDK12基因在肿瘤临床应用的明星之路 - 知乎
目前已知cdk12有三种主要功能：（1）cdk12磷酸化rna聚合酶polⅡ，促进转录的延伸；（2）cdk12与rna加工因子相互作用，调控剪接；（3）介导伴转录的rna聚合酶Ⅱ磷酸化 …
肿瘤潜在新靶标：CDK12 - 药时代DrugTimes
2021年1月27日 · cdk12是一种未来可期的癌症治疗靶标，在癌症发展中具有特定的背景作用，因此提供了一种低毒性的治疗方法。但是， 目前对cdk12生物学功能的理解被cdk12同源的cdk13 …
Gene expression regulation by CDK12: a versatile kinase in
2020年5月25日 · Here, we discuss the diverse roles of CDK12 in gene expression regulation and human cancer, focusing on newly identified CDK12 kinase functions in cellular processes and …
CDK12在不同恶性肿瘤中扮演的角色不同， 在前列腺癌（prostatic cancer, PCA）中，CDK12 发挥着抑癌基因的功能。2021年的一项研究表明， 前列腺癌和卵巢癌是CDK12基因发生变异频 …
CDK12 - Wikipedia
CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene. [5] [6] [7] This enzyme is a member of cyclin-dependent kinase protein family.
CDK12 : A Potent Target and Biomarker for Human Cancer Therapy
Cyclin-dependent kinase 12 (CDK12) is an important transcription-associated CDK. It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage …
CDK12 is a potential biomarker for diagnosis, prognosis and ...
2024年3月19日 · Cell cycle-dependent protein kinase 12 (CDK12) plays a key role in a variety of carcinogenesis processes and represents a promising therapeutic target...
CDK12: an emerging therapeutic target for cancer - PubMed
CDK12 has been demonstrated to specifically upregulate the expression of genes involved in response to DNA damage, stress and heat shock. More recent studies have implicated CDK12 …
Eur J Med Chem | 深度学习模型筛选CDK12抑制剂的开发、验证与 …
4 天之前 · cdk12是一种转录相关的细胞周期蛋白依赖性激酶，在dna复制、转录、损伤修复等过程中发挥重要作用，并与多种癌症相关。cdk12与cdk13共享较高序列相似性，导致特异性抑制 …