Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene. [5] [6] It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. [7] The protein encoded by this gene is a member of the cyclin-dependent kinase, (CDK) family, which includes CDK4. [8]

被激活的cyclin D-CDK4/6复合物磷酸化 视网膜母细胞瘤相关蛋白 (retinoblastoma-associated protein, Rb),进而使转录抑制复合物Rb-E2F解聚，释放E2F转录因子。 接着，游离的E2F激活细胞进入S期和DNA复制所需的相关基因。 另外，CDK4/6的活性受到INK4家族蛋白 (p16INK4A, p15INK4B, p18INK4C, and p19INK4D)以及Cip和Kip (尤其是p21CIP1 and p27KIP1)家族蛋白的调节 (图1)。 2. CDK4/6蛋白. CDKs是一个保守的激酶家族。 氨基酸序列分析显示CDK4和CDK6 …

2024年12月24日 · CDK6 (Cyclin Dependent Kinase 6) is a Protein Coding gene. Diseases associated with CDK6 include Microcephaly 12, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects.

CDK，即周期蛋白依赖性激酶 (cyclin-dependent kinases)是与细胞周期进程相对应的一套Ser/Thr激酶系统。 各种CDK沿细胞周期时相交替活化，磷酸化相应底物，使细胞周期事件有条不紊地进行下去。

2022年3月18日 · Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular transition into S phase and are important for the initiation, growth and survival of many cancer types....

Cyclin‐dependent kinase 6 (CDK6) acts as a chromatin‐bound cofactor that in a kinase‐independent manner induces transcription of genes regulating angiogenesis, cell cycle inhibition, stem cell activation and immune response.

周期蛋白依赖性激酶6 （英語： Cyclin-dependent kinase 6， CDK6） 是一种由 基因 CDK6编码的 激酶，由 周期蛋白 激活。 具体来说，CDK6受 周期蛋白D 激活，受CDK抑制蛋白抑制。 CDK6属于 周期蛋白依赖性激酶 （CDK）家族，其中包括 周期蛋白依赖性激酶4 （CDK4）。 ^ 與周期蛋白依赖性激酶6相關的疾病；在維基數據上查看/編輯參考. ^ 對Cyclin dependent kinase 6起作用的藥物；在維基數據上查看/編輯參考. ^ Human PubMed Reference:.

2022年1月14日 · Cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) and their activating partners, D-type cyclins, link the extracellular environment with the core cell cycle machinery. Constitutive activation of cyclin D–CDK4/6 represents the driving force of …

CDK6 is a novel predictive and prognosis biomarker correlated with immune infiltrates in multiple human neoplasms, including small cell lung carcinoma. Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis. FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy.

Ubiquitous expression in thymus adult (RPKM 7.), lung adult (RPKM 3.6) and 26 other tissues. 该基因编码细胞周期蛋白依赖性激酶蛋白家族的成员，该蛋白在细胞周期的进程和调节中起着重要作用。 编码的蛋白质与 D 型细胞周期蛋白结合形成活性激酶复合物，以调节细胞周期 G1 期的进程。 缺乏编码蛋白的小鼠表现出胸腺和脾脏发育不全，以及造血缺陷，例如巨核细胞和红细胞数量减少。 该基因的假基因已在 4 号染色体上定义。 [RefSeq 提供，2015 年 8 月]