Cyclin-dependent kinase 8 - Wikipedia
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK8 and cyclin C associate with the mediator complex and regulate transcription by …
CDK8 Gene - GeneCards | CDK8 Protein | CDK8 Antibody
Dec 24, 2024 · CDK8 (Cyclin Dependent Kinase 8) is a Protein Coding gene. Diseases associated with CDK8 include Intellectual Developmental Disorder With Hypotonia And …
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
Jan 14, 2019 · CDK8 and its paralog, CDK19, collectively termed 'Mediator Kinase,' are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and …
CDK8 is a positive regulator of transcriptional elongation
Jan 24, 2010 · CDK8 is a kinase found in some Mediator complexes and has been implicated in oncogenesis. Now it is shown to be a positive regulator of transcription elongation at …
CDK8 cyclin dependent kinase 8 [ (human)] - National Center for ...
CDK8 regulates the transcription factors turnover, C-terminal domain phosphorylation, and regulates the activator or repressor functions. (Review) Cdk8 is required for stress-induced …
The human CDK8 subcomplex is a molecular switch that controls …
Notably, CDK8 has been shown to phosphorylate several transcription factors in yeast, and this phosphorylation triggers nuclear export and transcription factor degradation by the proteasome …
CDK8 and CDK19: positive regulators of signal-induced ... - PubMed
Aug 11, 2023 · CDK8/19 inhibition under basal conditions initially downregulated a small group of genes, most of which were inducible by serum or PKC stimulation. Prolonged CDK8/19 …
Regulatory functions of the Mediator kinases CDK8 and CDK19
The CDK8 kinase exists in a 600 kDa complex known as the CDK8 module, which consists of four proteins (CDK8, CCNC, MED12, MED13). The CDK8 module associates with regulatory sites …
CDK8 is a colorectal cancer oncogene that regulates β-catenin
Sep 14, 2008 · CDK8, a general transcriptional regulator, functions in part by enhancing the activity of the Wnt signalling pathway. Morris et al. report that E2F1, a transcription factor that …
Salt stress activates the CDK8-AHL10-SUVH2/9 module to
Mar 12, 2025 · The CDK8-AHL10-SUVH2/9 module is critical for transcriptional dynamics in response to salt stress. Salt stress has devastating effects on agriculture, yet the key …