Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell ... - PubMed
Cyclin-dependent kinases of the mediator complex (CDK8 and CDK19) were described as a signaling intermediates in NK cells. Here, we report for the first time the development and use …
Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to ...
2025年1月31日 · Here, we show that short IL-18 generated by caspase-3 cleavage in cancer cells translocates into the nucleus, selectively affects STAT1 activity and thereby mobilizes NK cells …
NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses
2018年4月1日 · Because knockdown of CDK8 in a natural killer (NK) cell line enhances cytotoxicity and NK cells provide the first line of immune defense against transformed cells, we …
Selective and potent CDK8/19 inhibitors enhance NK cell activity …
We propose new strategies for the development of CDK8/19 inhibitors by: (i) using CDK8/19 inhibitors as mediators of NK cell activity against solid cancers, as opposed to as tumor …
CDK8 as a therapeutic target for cancers and recent developments …
2019年2月15日 · Overexpression of CDK8 has been observed in various cancers. It mediates aberrant activation of Wnt/β-catenin signaling pathway, which is initially recognized and best …
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity ...
2013年8月15日 · We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of …
NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses
Because knockdown of CDK8 in a natural killer (NK) cell line enhances cytotoxicity and NK cells provide the first line of immune defense against transformed cells, we asked whether inhibiting …
CDK8-mediated STAT1-S727 phosphorylation restrains NK cell ... - PubMed
2013年8月15日 · We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor cells, accompanied by increased expression of …
Triple-negative breast cancer cells rely on kinase-independent ...
2021年10月23日 · Recent in silico studies have revealed an inverse correlation between recurrence-free survival and the level of cyclin-dependent kinase 8 (CDK8) in breast cancer …
CDK8 maintains stemness and tumorigenicity of glioma stem …
2021年3月16日 · CDK8 has been shown to attenuate natural killer (NK) cell cytotoxicity and tumor surveillance . Moreover, CDK8 knockout in NK cells was shown to prolong survival in a mouse …