Our findings suggest that the regulation of c-Myc in breast cancer cells is dependent on the molecular subtype, and that β-catenin-mediated regulation of c-Myc and p21 may control the …

β-catenin regulates c-Myc and CDKN1A gene expression. To understand how β-catenin regulates c-Myc expression in breast cancer, we examined c-Myc mRNA and protein expression after …

In the present analysis, we have addressed the role of MYC and CDKN1A in the Wnt/β-catenin response that is required for developmentally scheduled hyaloid vessel regression. This has …

2023年4月24日 · Inhibition of c-MYC with the dominant-negative Omomyc protein relieves the DNA damage in CIII-deficient hepatocytes in vivo. Our results connect primary OXPHOS …

2021年1月11日 · Our RT–qPCR results showed that MYC repressed the mRNA level of CDKN1A and CDKN2B (Fig EV2H), indicating a transcriptional regulation by MYC. These data suggest …

2018年6月14日 · We investigated whether the hyaloid Wnt response was linked to the oncogene Myc, and the cyclin-dependent kinase inhibitor CDKN1A (P21), both established regulators of …

c-MYC stimulates cell proliferation through the suppression of cyclin-dependent kinase (CDK) inhibitors including P15 (CDKN2B) and P21 (CDKN1A). It also activates E-box-mediated …

2015年2月11日 · β-catenin regulates c-Myc and CDKN1A expression in breast cancer cells. We previously reported that the Wnt pathway is preferentially activated in basal-like breast cancer.

2009年4月1日 · Here we present the expression chronologies of the target genes Ccnd1 (encoding for cyclin D1), Myc (c-Myc), Cdkn1a (p21 CIP1/WAF1), Tfrc (Transferrin receptor 1), …

2015年2月8日 · In addition, CDKN1A mRNA and p21 protein expression were significantly increased in all breast cancer cell lines upon β-catenin silencing. Interestingly, inhibiting β …