2024年12月24日 · CDKN1B (Cyclin Dependent Kinase Inhibitor 1B) is a Protein Coding gene. Diseases associated with CDKN1B include Multiple Endocrine Neoplasia, Type Iv and Primary Hyperparathyroidism. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Defective binding of RB1 mutants to E2F1, (E2F2, E2F3).

Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. [5] It encodes a protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins.

该基因编码一种细胞周期蛋白依赖性激酶抑制剂，与 CDK 抑制剂 CDKN1A/p21 具有有限的相似性。 编码的蛋白质结合并阻止细胞周期蛋白 E-CDK2 或细胞周期蛋白 D-CDK4 复合物的激活，从而控制 G1 期的细胞周期进程。 这种蛋白质的降解由其 CDK 依赖性磷酸化和随后的 SCF 复合物泛素化触发，是细胞从静止状态转变为增殖状态所必需的。 该基因的突变与多发性内分泌腺瘤 IV 型 (MEN4) 相关。 [RefSeq 提供，2014 年 4 月]

The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division.

Chromosome 12: 12,867,992-12,875,305 forward strand. This gene has 4 transcripts (splice variants), 2 paralogues and is associated with 64 phenotypes. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?db=core;g=ENSG00000111276;r=12:12867992-12875305;time=1740417039702.702" failed to load.

Cyclin-dependent kinase inhibitor 1B (CDKN1B) was identified as a direct target of negative regulation by miR-222-3p in NP cells, and expression of miR-222-3p was found to be negatively correlated with that of CDKN1B in intervertebral disc degeneration tissue.

The CDKN1B gene, encoding for the CDK inhibitor p27 kip1, is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine neuroendocrine tumors. Lessons learned from small intestine neuroendocrine tumors suggest that CDKN1B mutations could be subclonal, raising the question of whether a deeper sequencing ...

2025年2月20日 · Clinical resource with information about CDKN1B, Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians., Multiple endocrine neoplasia type 4, …

2025年2月9日 · Title: Germline CDKN1B variant type and site are associated with phenotype in MEN4. RNF4 promotes tumorigenesis, therapy resistance of cholangiocarcinoma and affects cell cycle by regulating the ubiquitination degradation of p27kip1 in the nucleus.

CDKN1B, or p27(KIP1), is a cyclin-dependent kinase inhibitor that blocks the cell cycle in the G0/G1 phase upon differentiation signals or cellular insult. CDKN1B also regulates cell motility and apoptosis (summary by Cuesta et al., 2009).