摘要:目的探究一种改善二氢卟吩e6(Chlorin e6,Ce6) 水溶性的简便策略,并在细胞水平对其光动力治疗性能进行测试。 方法利用生物营养素胆碱(Choline) 与进行超分子复合,制备得到高水溶性光敏剂CHCe6。 采用光谱法对光敏剂CHCe6 的光物理性质( 如紫外- 可见吸收光谱、 单线态氧量子产率等) 进行表征。 利用紫外- 可见吸收光谱分析光敏剂CHCe6...

Oct 1, 2024 · Chlorin e6 (Ce6) is a photosensitizer with high efficiency and low dark toxicity. At the same time, elemene (ELE) contains high-efficiency and low-toxicity anti-cancer active ingredients, which can effectively penetrate tumor tissue and inhibit its recovery and proliferation.

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer [1] [2] [3].

Nov 1, 2022 · The size and morphology of the resulting DSPE-PEG-Ce6 micelles were characterized by transmission electron microscopy (TEM), and the results confirmed their spherical shape with an average diameter of 23.1 ± 4.9 nm (Fig. 1 a and b).

In this study, we develop a transdermal-enhancing peptide (TD)-modified cationic liposome that simultaneously encapsulated with photosensitizer chlorine 6 (Ce6) and immunoadjuvant CpG, denoted as Ce6/CpG@Lip-TD, to mediate photo-immunotherapy of superficial tumors via …

Mar 10, 2024 · Our findings indicate the multifunctionality of Fe-CDs@Ce6 in effectively combining ferroptosis/PDT therapy, tumor targeting and MRI imaging, which enables Fe-CDs@Ce6 to become promising biocompatible nanoplatform for the treatment of melanoma.

Mar 6, 2018 · 利用Pd@Pt纳米片的过氧化氢酶活性即分解过氧化氢产生氧的能力改善了肿瘤的乏氧微环境，同时Pd@Pt纳米片负载光敏剂二氢卟酚（Ce6）可以有效地将其递送到肿瘤组织，实现增强肿瘤特异性的PDT。 在材料的制备过程中，首先用双官能团PEG（SH-PEG-NH 2）修饰Pd@Pt 纳米片，然后将Pd@Pt-PEG进一步与光敏剂Ce6共价结合，得到Pd@ Pt-PEG-Ce6纳米复合材料。 Pd@Pt-PEG-Ce6具有良好的生物相容性，较长的血液循环半衰期，有效的肿瘤富集和极好 …

Ce6与纳米颗粒的耦联能有效通过改变肿 瘤微环境而产生靶向性肿瘤杀伤作用，这也是相 较历代光敏剂而言最大的突破——PDT 特异性清 除肿瘤组织而避免正常组织受损。 2 Ce6的简介及其在恶性肿瘤治疗中的应用 叶绿素α的基本碳架是由4个吡咯子环桥连

Mar 9, 2021 · Ce6通常可由脱镁叶绿酸 a 合成而得，是一种良好的光敏剂，生物活性与脱镁叶绿酸 a 相近。 Ce6产生单线态氧的效率很高，因为适合开发用于肿瘤的光动力治疗。

鞠课题组通过将氯e6（Ce6）与氮化碳材料集成，构建高性能、无金属复合光催化剂，其制备方法如图1a所示。 材料合成和表征结果表明，与Ce6和氮化碳材料相比，N缺陷的氮化碳和Ce6复合材料具有一系列优点，如更好的光吸收性能和更高的光生载流子分离效率。