2008年10月1日 · The CEV and EEV forms are important for virus dissemination. CEVs induce the formation of actin tails from the cell surface that drive virions towards uninfected cells, and EEVs mediate longer-range dissemination in vitro and probably within the host also [2].

痘苗病毒（Vaccinia Virus、VACV或VV）是一种大型复杂的包膜病毒，属于核质大DNA病毒(Nucleo-Cytoplasmic Large DNA Virus)家族的正痘病毒(Orthopoxvirus)。 它有一个线性双链DNA基因组，长度为194711个碱基对(WR株)，可编码约250个基因，末端重复序列(Terminal Repeat)的末端形成了末端 ...

The rapid spread of VACV from cell to cell requires early expression of proteins A33 and A36 on the cell surface, contact of this complex by a CEV/EEV and polymerization of actin to drive superinfecting EEV away towards uninfected cells.

2022年12月30日 · 痘苗病毒（Vaccinia virus，VACV）是实验室广泛使用的痘病毒模型，曾被用于制备天花疫苗，其中M-63（苏联）、Lister（英国）、天坛（中国）以及Wyeth、IHD（美国）VACV毒株使用最广泛。

2004年12月1日 · Vaccinia virus (VACV) can spread from cell-to-cell in several ways (Fig. 3). (i) Direct spread to the adjacent cell can be mediated by cell lysis, release of IMV and re-infection of surrounding cells. (ii) CEV particles present on the cell surface can be driven into surrounding cells by actin tails.

2008年9月26日 · Vaccinia virus (VACV) (see Box 1 for taxonomy and a brief historical background) has a complex morphogenic pathway that culminates in the formation of two distinct infectious virions that are surrounded by different numbers of membranes. The first virion produced, which is called intracellular mature virus (IMV), is surrounded by a single ...

IEV is formed by wrapping of IMV with intracellular membranes, and is an intermediate between IMV and CEV/EEV that enables efficient virus dissemination to the cell surface on microtubules. CEV induces the formation of actin tails that drive CEV particles away from the cell and is important for cell-to-cell spread.

Vaccinia virus (VACV) intracellular enveloped virus (IEV) particles are transported to the cell periphery on microtubules where they fuse with the plasma membrane to form cell-associated enveloped virus (CEV). Two IEV-specific proteins, F12L and A36R, are implicated in mediating transport of IEV.

2015年1月15日 · Vaccinia virus (VACV) is a large double-stranded DNA virus with a complex cytoplasmic replication cycle that exploits numerous cellular proteins. This work characterises the role of a proviral cellular protein, the small GTPase RAB1A, in VACV replication.

2018年11月12日 · By providing new molecular understanding of VACV-induced cell migration, using virus mutants and inhibiting EGFR signalling at multiple levels, we show that infected cell motility is directly ...