A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, …
2004年4月15日 · In this study, we demonstrate that different Toll-like receptor (TLR) ligands induce distinct dendritic cell (DC) activation and immune responses in vivo. Thus, Escherichia …
TH2 cell development and function - Nature Reviews Immunology
2017年10月30日 · T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic …
Dendritic Cell-Mediated Th2 Immunity and Immune Disorders
Pam-3-Cys, a TLR2 ligand (TLR2L), stimulates DCs via TLR2, leading to DC-mediated Th2 immune responses via the ERK-cFos pathway. Following ERK activation by Pam-3-Cys, the …
c-Fos：神经元活性与记忆形成的分子标记
2024年12月26日 · 在静息状态下，c-Fos在细胞内的表达水平非常低，但一旦细胞受到外界刺激，如生长因子、细胞因子、神经递质、多肽激素或应激等，c-Fos的表达会迅速而短暂地诱导 …
Bach2–Batf interactions control Th2-type immune response by
2016年9月1日 · We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2–Batf complex antagonizes the …
Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse ...
In this study, we investigated the role of TLR2-induced Tpl2-ERK signaling in the regulation of pro- and anti-inflammatory markers (particularly IL-12/23p40 and IL-10) in macrophages and …
N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER
2006年12月11日 · Herein, we describe the phosphorylation of c-Fos tyrosine (tyr) residues and demonstrate its regulatory implications in events related to c-Fos/ER association and c-Fos …
《自然免疫》报道上海生科院转录因子c-Fos/AP1调控T细胞受体研 …
2008年6月20日 · 刘小龙研究组的博士研究生王晓明等研究人员发现介导D-J重排的D片段3′端RSS含有物种间高度保守的转录因子c-Fos/AP-1结合位点，在小鼠Tcrb重排过程中，c-Fos高 …
T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell ...
In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naïve CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, …
组织透明化三维成像技术揭示小鼠整脑c-FOS蛋白分布 - 知乎
该原理图描绘了连续刷每根胡须，依次激活啮齿类动物体感觉皮层中特定“barrels”中的神经元群，通过c-FOS表达上调来识别 (用浅蓝色、橙色和绿色方块表示)。 因此，对c-FOS表达的检测 …