2024年12月24日 · CIT (Citron Rho-Interacting Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with CIT include Microcephaly 17, Primary, Autosomal Recessive and Primary Autosomal Recessive Microcephaly. Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle.

Citron Rho-interacting kinase is an enzyme that in humans is encoded by the CIT gene. [5][6] Citron is a 183 kDa protein that contains a C6H2 zinc finger, a PH domain, and a long coiled-coil forming region including 4 leucine zippers and a rho / rac binding site.

2025年2月8日 · This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis.

2025年1月4日 · This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis.

该基因编码一种在细胞分裂中起作用的丝氨酸/苏氨酸蛋白激酶。 与驱动蛋白 KIF14 一起，该蛋白定位于中央纺锤体和中体，并发挥促进有效胞质分裂的作用。 这种蛋白质参与中枢神经系统发育。 该基因的多态性与双相情感障碍和精神分裂症的风险有关。 可变剪接导致多个转录本变体。 [RefSeq 提供，2011 年 8 月] This gene encodes a serine/threonine-protein …

2016年8月25日 · HGNC Approved Gene Symbol: CIT. Activated Rho GTPases (see 602924) trigger distinctive kinase cascades. In particular, ROCK (see ROCK1, 601702) binds to Rho, and its kinase activity is moderately stimulated by this association.

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, th is protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development.

2024年11月27日 · This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis.

cit 与神经系统有着密切的关系,cit 中隐性遗传致命变种是头小畸形和新生儿死亡的基因基础,并严重损害了胚胎后期和出生后的神经发生。 CIT 可促进人类免疫缺陷病毒的生成。

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development.