Kuru, a transmissible spongiform encephalopathy, is a disease of the nervous system that causes physiological and neurological effects which ultimately lead to death. It is characterized by …

Transmissible spongiform encephalopathies (TSEs) or prion diseases are the names given to the group of fatal neurodegenerative disorders that includes kuru, Creutzfeldt-Jakob disease …

Kuru, the first human prion disease was transmitted to chimpanzees by D. Carleton Gajdusek (1923–2008). In this review, we summarize the history of this seminal discovery, its …

Murine adapted human agents, including sporadic CJD (sCJD), New Guinea kuru, and Japanese CJD agents, display particularly distinct incubation times and maximal infectious brain titers. …

2003年6月1日 · In kuru, presumed to be due to a peripheral route of infection, cerebellar signs predominate in the early stages as in human pituitary hormone recipients, whereas in …

Kuru and the transmissible virus dementias Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker syndrome (GSS) belong to the group of virus-induced slow infections …

2012年1月1日 · The recognition of kuru as a neurodegenerative (i.e. non inflammatory) disease that is also transmissible (i.e. infectious) and the subsequent experimental transmission of …

The cause of sporadic Creutzfeldt-Jakob disease (CJD) is unknown, hereditary cases are associated with mutations of the prion protein gene (PRNP) and acquired forms are caused by …

2008年11月27日 · A comparison of the phenotype of kuru with more recent subtyping of Creutzfeldt–Jakob disease (CJD) shows that the kuru cases resemble those cases of sporadic …

2025年2月6日 · Kuru’s devastating effects and mysterious nature made it a subject of intense scientific inquiry. Researchers studying the disease uncovered fundamental mechanisms of …