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A creatine kinase (CK) test measures the amount of creatine kinase in your blood. Elevated CK levels may indicate skeletal muscle, heart or brain damage or degeneration — either chronic (long-term) or acute (short-term). Other names for a creatine kinase test include: CK total. CK creatine. Phosphokinase CPK.

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Creatine kinase (CK) is a “leakage” enzyme present in high concentrations in the cytoplasm of myocytes (skeletal and cardiac primarily) and brain and is the most widely used enzyme for evaluation of muscular disease. In muscles, CK functions by making ATP available for contraction by phosphorylating ADP from phosphocreatine.

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CK is the enzyme responsible for reversible transfer of the terminal phosphate group of ATP to creatine to form phosphocreatine. Serum CK begins to rise 2 to 12 hours after the destruction of more than 200 g of muscle, with the peak level occurring between 1 and 3 days. Levels decline within 3 to 5 days after the muscle injury ceases.