Sep 1, 2017 · Outer membrane vesicles (OMVs) are naturally non-replicating, highly immunogenic spherical nanoparticles derived from Gram-negative bacteria. OMVs from pathogenic bacteria have been successfully used as vaccines against bacterial meningitis and sepsis among others and the composition of the vesicles can easily be engineered.

Jan 1, 2015 · A growing number of gram-negative bacteria has been reported to secrete outer membrane vesicles (OMV) whose functions are frequently involved in the delivery of active substances to a host and/or the modulation of a host immune response; for recent reviews see Amano et al. (2010), Ellis and Kuehn (2010), MacDonald and Kuehn (2012), Berleman and ...

Jan 28, 2023 · Engineered outer membrane vesicles (OMVs) derived from Gram-negative bacteria are a promising technology for the creation of non-infectious, nanoparticle...

Nov 17, 2021 · Outer membrane vesicles (OMV) represent a promising platform for the development of vaccines against bacterial pathogens. More recently, bacteria have been genetically modified to increase OMV yield and modulate the design of resulting particles, also named generalized modules for membrane antigens (GMMA).

Jan 1, 2022 · Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen, thus efficiently facilitating antitumor adaptive immunity. Bacteria-derived outer membrane vesicles (OMVs) are an excellent candidate due to their abundance of pathogen associated molecular patterns.

Dec 20, 2022 · Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and in maintaining bacterial fitness.

Oct 5, 2023 · Outer membrane vesicles (OMVs) represent a viable platform for vaccine development, and some OMV-based vaccines are currently licensed and are in clinical use.

Mar 6, 2021 · Outer Membrane Vesicles (OMV) are receiving great attention as vaccine platforms. OMV are complex molecules and few data have been collected so far on their stability. OMV produced by bacteria, genetically modified to increase their spontaneous release, simplifying their production, are also known as Generalized Modules for Membrane Antigens ...

Jan 25, 2024 · 近日，专注创新细菌疫苗研发的合成生物学公司 上海羽冠生物技术有限公司 （简称“羽冠生物”）与全球领先的疫苗CDMO公司 药明海德（WuXi Vaccines） 签署了技术开发协议，双方将加速推进羽冠生物创新细菌疫苗的开发。 根据协议，羽冠生物将借助药明海德在疫苗领域精深的技术专长、丰富的监管经验、一流的质量体系、先进的CMC开发能力和充沛的GMP产能，加速推进创新细菌疫苗管线的生产、临床申报以及国际化布局。 双方将充分利用各自优势和资源 …

Outer membrane vesicles (OMVs) produced by Gram-negative bacteria are mediators of cell survival and pathogenesis by facilitating virulence factor dissemination and resistance to antimicrobials. Studies of OMV properties often focus on ...