2013年6月1日 · Very low birth weight (VLBW) and premature infants are at risk for developing postnatal cytomegalovirus (CMV) disease, including CMV-related sepsis-like syndrome (CMV-SLS) for which in the United States are lacking.METHODS:.

Very low birth weight (VLBW) and premature infants are at risk of developing postnatal cytomegalovirus (CMV) disease, including CMV-related sepsis-like syndrome (CMV-SLS). Estimates of breast milk-acquired CMV infection and disease among these infants in the United States are lacking.

Symptomatic postnatal CMV infection was diagnosed in 1.3% of VLBW infants, most commonly among infants with BW < 1,000 g with respiratory instability and thrombocytopenia. Similar to late-onset bacterial infection, symptomatic postnatal CMV infection may be an independent contributor to the development of BPD.

Breast milk-acquired CMV infection presenting with CMV-SLS is relatively rare. Prospective studies to better define the burden of disease are needed to refine guidelines for feeding breast milk from CMV-seropositive mothers to VLBW and premature infants.

2023年5月18日 · HM-acquired symptomatic CMV infection rate is low and its impact on clinical course was not serious in our VLBW infants. However, evidences showing poor neurodevelopmental outcome in later life, we need to generate a guideline to protect VLBW infant form HM transmitted CMV infection.

We aimed to determine the incidence and association with outcomes of congenital CMV in very low birth weight (VLBW) preterm infants. Methods: VLBW infants born in 1993 to 2008 and admitted to the University of Alabama in Birmingham Regional Neonatal ICU were screened on admission for congenital CMV.

Transfusion-transmitted cytomegalovirus (TT-CMV) and breast milk-transmitted CMV (BM-CMV) infections can cause serious morbidity and mortality in immunologically immature, very low birth weight (VLBW) infants (birthweight ≤1500 grams).

CMV-tested infants were of significantly lower gestational age and BW compared with untested VLBW infants (p < 0.001). Respiratory decompensation and thrombocytopenia were the findings most commonly associated with infection.

研究者将混合比例与人群为基础的cmv血清阳性率、母乳喂养率、vlbw出生率以及早产儿出生率相比较，研究美国每年经母乳感染cmv和cmv-sls婴儿的患病率。

1.2 极低出生体质量(vlbw)婴儿围生期cmv感染. 足月儿围生期cmv感染大多为无症状感染，值得关注的是早产儿特别是vlbw婴儿免疫力低下，vlbw婴儿围生期cmv感染损伤较足月儿重。