Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone. Part of mitochondrial respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Leigh disease; and Parkinson's disease. [provided by Alliance of Genome Resources, Apr 2022] 生物活性分子 (1)

Jul 19, 2021 · 该研究揭示了一条进化上保守的NAD+再生通路Glycerol-3-phosphate （Gro3P） biosynthesis， 并为呼吸链复合物I缺失导致的神经退行性疾病提供了治疗靶点。 Gro3P biosynthesis是进化上保守的NAD+再生通路. 作者对人基因组中NAD + 依赖的代谢酶及其反应做了系统分析挑选出8条潜在的NAD+再生通路。 由于以酵母和线虫为代表的低等生物可以承受相当严重的呼吸链损毁 （酵母甚至可以在无氧（无呼吸）环境中生长） ，提示它们能够有效再 …

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Dec 25, 2024 · MT-ND3 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 3) is a Protein Coding gene. Diseases associated with MT-ND3 include Mitochondrial Complex I Deficiency, Mitochondrial Type 1 and Leigh Syndrome, Nuclear .

Nov 4, 2021 · The enigmatic active/deactive transition of complex I is linked to the exposure state of the critical ND3-Cys39 residue, functioning as critical indicator. Burger et al. show that Cys39 is exposed during complex I-linked respiration with important implications for the understanding of the active/deactive transition and complex I function.

We describe a new mitochondrial DNA mutation in a male infant who presented clinical and magnetic resonance imaging features of Leigh syndrome and died at the age of 9 mo. The patient’s development...

Sep 19, 2017 · The Nd-based crystal powder random laser provides speckle-free transmission and reflection infrared images with higher values of contrast to noise ratio than those obtained with the narrowband laser. These results open up new possibilities to enhance the field of high resolution imaging for optoelectronic and biomedical applications.

Dec 1, 2023 · Nd 3+ ion, as one of the earliest active ions investigated, is an active ion that can achieve high efficiency laser output in near infrared band. The Nd 3+ ion has an electron configuration of [Xe]4f 3 [4].

Jun 1, 2022 · Herein, we developed a new nanotheranostic agent − Nd 3+ -sensitized upconversion nanoparticles core for dual modal imaging (i.e., upconversion luminescence imaging and magnetic resonance imaging) and antimony nanoshell for photothermal therapy (PTT).

Feb 8, 2025 · A novel recurrent mitochondrial DNA mutation in ND3 gene is associated with isolated complex I deficiency causing Leigh syndrome and dystonia. Sarzi E, Brown MD, Lebon S, Chretien D, Munnich A, Rotig A, Procaccio VSarzi E, et al .