In this chapter we discuss the findings of neuroimaging studies that investigated the processing of itch and scratching in the superior relays of central nervous system (CNS), when itch was induced experimentally or when pathological pruritus was studied as a …

The increase of histamine-induced itch during the first 8 seconds of the 25°C stimulation periods (as compared with saline) is associated with an increase (red) and decrease (blue) of activation in various brain structures subserving sensory, emotional, cognitive, and motivational aspects of itch processing. As an example, the averaged ...

Central neural sensitization in itch refers to the abnormal amplification and dysregulation of itch signals in the central nervous system (CNS), which includes the brain and spinal cord, resulting in heightened responsiveness and sensitivity to itch stimuli.

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a characteristic behavioral response (scratching).

Neuropathic itch results from nerve injury and can arise from diseases or disorders of the central nervous system (CNS) or peripheral nervous system, such as neuropathy, multiple sclerosis, brain tumors, and nerve compression or irritation.

2025年3月4日 · Here, we identify modality-specific neuronal populations in layer II/III of the ACC in mice involved in pain and itch processing. Using a synapse labeling tool, we show that pain- and...

In this review, we summarize the current understanding of the molecular and neural mechanisms of itch by starting in the periphery, where itch is initiated, and discussing the circuits involved in itch processing in the CNS. Itch (also known as pruritus) is an uncomfortable everyday expe-rience that evokes a desire to scratch.

2018年5月2日 · Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a characteristic behavioral response (scratching). Itch interacts with the other sensory modalities at multiple locations, …

Itch, also known as pruritus, is generally defined as an unpleasant sensation that evokes an instinctive urge to scratch. Similar to pain, itch evolved as a protective mechanism against harmful external elements. Whereas pain triggers immediate withdrawal from hazard, itch-induced scratching removes irritants from the skin.

2020年6月16日 · In this review, we summarize the progress in elucidating the neural circuit mechanism of itch at spinal and supraspinal levels. Itch is defined as an unpleasant sensation that evokes a desire...