2005年3月25日 · In the present study, we demonstrated that COX-2 inhibits genotoxic stress-induced apoptosis by using an adenoviral COX-2 overexpression system. In addition, we found that COX-2 regulates the transcription function of p53 as evidenced by suppression of p53 target gene induction by COX-2 cotransfection.

2005年3月25日 · We showed that COX-2 is a downstream target gene of p53, whose expression is induced by p53 activation of the Ras/Raf/MAPK pathway. We also demonstrated that COX-2 inhibits DNA damage- or p53-induced apoptosis in loss-of-function models of COX-2.

2004年12月20日 · Here we report that the tumor suppressor p53 upregulates COX-2 expression and that COX-2 can in turn inhibit p53-dependent transcription. Additionally, a COX-2-selective inhibitor...

2002年11月1日 · Together, these results demonstrate that Cox-2 is induced by p53-mediated activation of the Ras/Raf/ERK cascade, counteracting p53-mediated apoptosis. This anti-apoptosis effect may be a mechanism to abate cellular stresses associated with p53 induction.

2021年5月10日 · We found that COX-2 inhibits the pro-senescent function of p53 under oncogenic RAS activation, by which it prevents oncogene-induced senescence (OIS) and induces neoplastic transformation.

2009年8月1日 · The p53-interacting region was critical for COX-2-mediated inhibition of p53 DNA-binding and transcriptional activity as well as p53- and genotoxic stress-induced apoptosis. In addition, an active site mutant of COX-2 (S516Q) as well as wild-type COX-2 potently inhibited p53 transcriptional activity and genotoxic stress-induced apoptosis.

COX-2在多种肿瘤组织中过量表达,COX-2活性和前列腺素合成的增加促进细胞增殖、血管新生、肿瘤细胞浸润及抑制细胞凋亡.许多应激和前炎症信号,如氧自由基和DNA损伤剂,可诱导COX-2和P53的表达,而P53作为一种转录因子在肿瘤中常因突变而失活.已有研究表明,P53和COX-2 ...

2002年11月1日 · Through expression array analysis, we identified cyclooxygenase 2 (Cox-2), whose expression was inducible by wild-type p53 and DNA damage. We also found that p53-induced Cox-2 expression results from p53-mediated activation of the Ras/Raf/MAPK cascade, as demonstrated by suppression of Cox-2 induction in response to p53 by dominant-negative Ras ...

The association of COX-2 and p53 with various anti-oxidant enzymes showed a significantly positive correlation between COX-2 expression and catalase activity and an inverse correlation between p53 expression and superoxide dismutase and catalase activity in the tumor tissue of patients given NAT.

2022年2月27日 · COX-2 can induce proliferation and angiogenesis via p53, p27 and vascular endothelial growth factor and also inhibit apoptosis by inducing the antiapoptotic factor Bcl-2, as well as activating antiapoptotic signaling through protein kinase B pathway in HCC [23].