免疫细胞表面的TLR9及其免疫调节作用 - 知乎 - 知乎专栏
Toll样受体9 （TLR9）是Toll样受体家族的成员之一，其可被病原体来源的非甲基化磷酸胞苷鸟苷DNA（ CpG DNA ）或人工合成的含非甲基化CpG的 寡核苷酸 （CpG ODN）激活，并通过其 …
Structural basis of CpG and inhibitory DNA recognition by Toll-like ...
2015年2月9日 · The nucleotide-sensing Toll-like receptor TLR9 triggers innate immune responses after recognizing microbial DNA containing CpG motifs. Toshiyuki Shimizu and colleagues …
Toll-like receptor 9 agonists and combination therapies ... - Nature
2022年7月28日 · In this review article, we describe the TLR9 signaling, the application of TLR9 agonists CpG-ODN in tumour biology, the delivery methods and focus on the combination …
Toll-like receptor 9, CpG DNA and innate immunity - PubMed
Recent studies indicate that mucosal or systemic delivery of CpG DNA can act as a potent adjuvant in a vaccine combination or act alone as an anti-microbial agent. Recently, it was …
TLR9激动剂-CpG ODNs - 知乎 - 知乎专栏
CpG-A ODNs刺激类浆树突细胞（pDC）可以较强的产生 IFN-a，但是会较弱的激活TLR9依赖的 NF-kB 信号通路，产生较少的促炎性细胞因子（如白细胞介素6）。 - CpG-B ODNs 是包含一 …
国家纳米科学中心林耀新/王浩团队Adv Mater.：负载CpG的智能纳 …
研究构建的肿瘤靶向型纳米机器人（CpG@NRT）可以有效地向toll样受体9 （TLR9）阳性肿瘤递送CpG，通过诱导肿瘤细胞的自噬效应激活免疫原性，进而有效提高肿瘤的免疫反应；同 …
TLR9 signals after translocating from the ER to CpG DNA in the …
2004年1月11日 · We show that CpG DNA binds directly to TLR9 in ligand-binding studies. CpG DNA moves into early endosomes and is subsequently transported to a tubular lysosomal …
Structural basis of CpG and inhibitory DNA recognition by Toll-like ...
2015年4月30日 · The molecular basis by which CpG-containing DNA (CpG-DNA) elicits immunostimulatory activity via TLR9 remains to be elucidated. Here we show the crystal …
肿瘤免疫治疗新势力：CpG-ODN的生物学机制与临床突破
2025年2月24日 · 在PD-1/PD-L1抑制剂等明星靶点之外，Toll样受体（TLR）信号通路因其先天免疫激活能力，成为近年来领域内的重要突破方向。 其中，以CpG寡聚脱氧核苷酸（CpG …
CpG‐ODN‐mediated TLR9 innate immune signalling and calcium ...
Exogenous CpG‐oligodeoxynucleotides (ODN) stimulate TLR9 mediate innate immune signalling, and have been used to study the pathogenesis of sterile inflammation.