2023年10月13日 · This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b, and to inhibit the classical, lectin, and alternative pathways of the complement cascade via the mechanisms of decay acceleration activity (DAA) and co ...

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. [3] [4] This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1.

2023年10月13日 · This review will focus on the extracellular domain of CR1 and detail how its highly duplicated domains work both separately and together to mediate binding to its main ligands C3b and C4b, and to inhibit the classical, lectin, and alternative pathways of the complement cascade via the mechanisms of decay acceleration activity (DAA) and co ...

The C3b/C4b receptor (CR1; 120620) is important in immune complex processing. On phagocytic cells it promotes the adherence and sometimes the endocytosis of C3b- and C4b-coated particles. CR1 is composed largely of a tandemly repeated motif of approximately 60 amino acids, the short consensus repeat (SCR).

2024年12月24日 · CR1L (Complement C3b/C4b Receptor 1 Like) is a Protein Coding gene. Diseases associated with CR1L include Alzheimer's Disease 1 and Nephronophthisis 1. An important paralog of this gene is CR1. Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3). Belongs to the receptors of complement activation (RCA) family.

2024年12月24日 · CR1 (Complement C3b/C4b Receptor 1 (Knops Blood Group)) is a Protein Coding gene. Diseases associated with CR1 include Malaria and Follicular Dendritic Cell Sarcoma. Among its related pathways are Complement cascade …

Human complement receptor 1 (CR1) is a membrane-bound regulator of complement that has been the subject of recent attempts to generate soluble therapeutic compounds comprising different fragments of its extracellular domain. This review will focus ...

2024年7月1日 · We identified LHR-ABCC, a soluble CR1 variant containing a duplicated C3b-binding C-terminal LHR-C domain that exhibited significantly enhanced alternative pathway inhibitory activity in vitro compared to CSL040.

Complement Receptor 1 (CR1), the receptor for C3b/C4b complement peptides (Iida et al., 1982) is present on different cells, plasma and urine. CR1 has drawn huge attention of the scientists because of its gene polymorphisms, structural variances, diversity of …

CR1 is the most versatile inhibitor of both classical and alternative pathway C3 and C5 convertases due to its decay-accelerating activity and co-factor activity for C3b/C4b cleavage. Moreover, CR1 plays a major role in immune complex clearance due to …