2024年8月30日 · Our study provides a single-cell full-length transcriptomic atlas of colorectal cancer (CRC), identifying tumor-specific/-associated RNA isoforms and highlighting their …

Colorectal cancer is an aggressive tumor with high global prevalence, and interestingly enhanced CPE expression has been documented in both colorectal cancer (CRC) cell lines and patient …

2024年7月8日 · Expanding the efficacy of immune checkpoint blockade (ICB) in colorectal cancer (CRC) presses for a comprehensive understanding of treatment responsiveness. Here, we …

2017年7月6日 · This study expands the view of CRC cell lines as accurate molecular models of primary carcinomas, and we present integrated multi-level molecular data of 34 widely used …

2015年4月30日 · Here we describe the mutational and gene expression analyses of 151 colorectal cancer (CRC) cell lines. We find that the whole spectrum of CRC molecular and …

2023年1月3日 · 本研究通过构建CRC类人小鼠转移复发模型， 揭示了一群EMP1高表达的HRC细胞对于转移定植至关重要，而LGR5+干细胞样肿瘤细胞对于CRC转移后的生长起关键作用。 …

2024年7月8日 · Expanding the efficacy of immune checkpoint blockade (ICB) in colorectal cancer (CRC) presses for a comprehensive understanding of treatment responsiveness. Here, we …

2023年12月7日 · A spatial multi-omic atlas uncovers the diverse genetic and transcriptomic landscape of human colorectal lesions along progression to malignancy, highlighting the …

We have developed a deep learning–based method to measure the similarity between CRC tumors and disease models such as cancer cell lines. Our method efficiently leverages …

2025年3月3日 · Colorectal cancer (CRC) progresses through a series of stages, marked by the accumulation of mutations in colonic epithelial cells [].The cancer cells generally become more …