Carbapenemase-producing Enterobacterales (CPE) bacteria are a critical global health concern; New Delhi metallo-β-lactamase (NDM) enzymes account for >25% of all CPE found in Switzerland. We characterized NDM-positive CPE submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance during a 2-year period (January 2019 ...

Carbapenems are last-line antibiotics used to treat serious multidrug-resistant infections. In the United States, about 2 -3% of Enterobacterales associated with healthcare-associated infections are resistant to carbapenems. CRE infections don’t respond to common antibiotics and invasive infections are associated with high mortality rates.

CP Isolates are defined as those testing positive for carbapenemase activity and/or any of the five targeted genes (KPC, NDM, VIM, IMP, OXA-48). Carbapenem-resistant Enterobacterales (CRE) isolates were resistant to ertapenem, imipenem, meropenem, or doripenem using antimicrobial susceptibility testing breakpoints.

cre 的治疗取决于感染部位、分离的病原体、耐药性概况和物种特异性天然耐药性（见表 1）。由于 cre 对首选抗生素产生了耐药性，因此有必要进行二线治疗。由于可能治疗的复杂性和可变性，计划应由体外药敏试验驱动。应咨询传染病专家和微生物学家。

In the case of bloodstream infections, CRE significantly increase the mortality rate up to 65.4% in comparison to carbapenemase-susceptible Enterobacteriaceae pathogens . CRE strains have a common mechanism of resistance against carbapenem antibiotics by producing carbapenemases .

Importance Carbapenem-resistant Enterobacteriaceae (CRE) producing the New Delhi metallo-β-lactamase (NDM) are rare in the United States, but have the potential to add to the increasing CRE burden. Previous NDM-producing CRE clusters have been attributed to person-to-person transmission in health care facilities.

碳青霉烯耐药肠杆菌科细菌（carbapenem resistant Enterobacteriaceae，CRE）定义为肠杆菌科细菌对亚胺培南、美罗培南或厄他培南等任一碳青霉烯类药物耐药，美国CDC定义基本一致，将CRE定义为在体外对至少一种碳青霉烯类耐药的肠杆菌科。 CRE感染/定植的高危因素包括：1）超广谱抗菌药物的使用（尤其是碳青霉烯类）；2）侵入性医疗器械的使用，如手术、呼吸机、尿管、PICC管等；3）免疫受损宿主人群的增加，尤其是老年高龄人群；4）近期住院史、住ICU …

2020年1月17日 · 全国 cre 监测网络显示 2012 至 2016 年间主要的碳青霉烯酶类型有 kpc-2（76.5%）和 ndm-1（9.3%）。 KPC-2 和 NDM-1 都可水解绝大多数β-内酰胺药物，包括碳青霉烯类；不同之处在于 KPC-2 为丝氨酸酶，水解氨曲南，能被新型酶抑制剂阿维巴坦所抑制，而 NDM 为金属酶，不 ...

2012年6月22日 · New Delhi metallo-beta-lactamase (NDM)–producing Klebsiella pneumoniae are resistant to extended-spectrum antimicrobials, including carbapenems. The resistance mechanism is highly transmissible and its presence substantially limits treatment options.

2018年10月23日 · 美罗培南-vaborbactam 是碳青霉烯类与β内酰胺酶抑制剂的复方制剂，体外对产 KPC 的 CRE 有抗菌作用，但对产 MBLs（NDM 或 VIM）或 OXA-48 的 CRE 无效。 III 期临床试验 TANGO I 证实了美罗培南-vaborbactam 在复杂性尿路感染，包括多种病原菌所致的急性肾盂肾 …