Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF 1, with the latter (CRF 1) now being the IUPHAR-recommended name. [4] In humans, CRF 1 is encoded by the CRHR1 gene at region 17q21.31, beside micrototubule-associated protein tau MAPT .

2024年12月24日 · CRHR1 (Corticotropin Releasing Hormone Receptor 1) is a Protein Coding gene. Diseases associated with CRHR1 include Anxiety and Depressive Disorder. Among its related pathways are GPCR downstream signalling and Activation of cAMP-Dependent PKA.

CRHR1 SNP rs110402 genotype plays a role in psychosocial neural processing and cortisol response in healthy adults. The activity in dACC may mediate effect of rs110402 on psychosocial stress processing in the healthy population. Moreover, level of dACC activation may be associated with stress vulnerability.

促肾上腺皮质激素释放激素 (CRH) 通过表达在VTA上多巴胺神经元的CRH 受体 1 (CRHR1) 调控应激相关的行为反应。 此外，敲除VTA脑区多巴胺神经元的CRHR1可促进焦虑样行为，敲除该区域抑制性神经元的CRHR1可发挥抗焦虑作用。 2022年3月23日 洛桑联邦理工学院 Carmen Sandi研究团队揭示了 应激状态 下不同焦虑水平中目标动机行为差异性的机制。 研究人员根据大鼠在 高架十字迷宫 开放臂停留时间定义 高焦虑大鼠 (开放臂停留时间与总时间的比值低于5%)和 低焦 …

2015年9月9日 · The corticotropin-releasing hormone receptor type 1 (CRHR1) plays an important role in orchestrating neuroendocrine, behavioral, and autonomic responses to stress. To identify molecules capable of directly modulating CRHR1 signaling, we performed a yeast-two-hybrid screen using the C-terminal intracellular tail of the receptor as bait.

该基因编码一种 G 蛋白偶联受体，该受体结合促肾上腺皮质激素释放激素家族的神经肽，这些激素家族是下丘脑-垂体-肾上腺通路的主要调节因子。 编码的蛋白质对于激活调节多种生理过程 (包括压力、繁殖、免疫反应和肥胖) 的信号转导通路至关重要。 可变剪接导致多个转录本变体。 该基因与上游 GeneID:147081 之间自然发生的通读转录导致转录物编码与该基因产物具有相似性的亚型。 [RefSeq 提供，2016 年 8 月]

2024年12月18日 · Here, we describe the generation of a novel transgenic mouse, the Crhr1 -FlpO mouse, which utilizes the codon-optimized flippase (FlpO) recombinase system driven by the Crhr1 promoter. We test the specificity of FlpO expression within CRHR1-expressing cells using two separate complementary methods.

2024年12月18日 · Corticotropin-releasing hormone (CRH) signaling through its cognate receptors, CRHR1 and CRHR2, contributes to diverse stress-related functions in the mammalian brain. Whereas CRHR2 is predominantly expressed in choroid plexus and blood vessels, CRHR1 is abundantly expressed in neurons in discrete b …

2024年1月25日 · Title: Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.

2012年7月6日 · The CRHR1 gene contributes to genetic susceptibility of aggressive behavior towards others in Chinese southwest Han population. CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents. Sumner JA, McLaughlin KA, Walsh K, Sheridan MA, Koenen KCSumner JA, et al. Psychoneuroendocrinology, 2014 May. PMID 24703172.