The evolutionarily conserved cullin family proteins can assemble as many as 400 distinct E3 ubiquitin ligase complexes that regulate diverse cellular pathways. CUL4, one of three …

2022年12月19日 · 研究表明，IMiDs主要通过结合CRL4 E3泛素连接酶 (CRL4CRBN) 复合物的底物受体蛋白Cereblon (CRBN) 发挥其抗骨髓瘤活性。 通过结合CRBN，IMiDs改变了其底物的 …

Here, the work provides an overview to address the role of CRL4 E3 ubiquitin ligase in cancer development and progression, and discuss the possible mechanisms of CRL4 ligase involving …

2015年12月15日 · Here, the work provides an overview to address the role of CRL4 E3 ubiquitin ligase in cancer development and progression, and discuss the possible mechanisms of CRL4 …

In this article, we will discuss the genetic function, molecular assembly and substrates of CUL4– RING ligases (CRL4s). We will compare CUL4’s pleiotropic functions across several species, …

2024年11月22日 · Our findings reveal that circRFWD2_369aa plays a crucial role in regulating the expression and ubiquitination of p27 in MM cells by forming complexes with DDB1 and CUL4A …

2009年10月8日 · Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative …

2009年11月1日 · In this article we discuss the genetic function, molecular assembly and substrates of CUL4–RING ligases (CRL4s). We compare the pleiotropic functions of CUL4 …

2022年9月16日 · It is now known that IMiDs exert their anti-myeloma activity mainly by binding cereblon (CRBN), the substrate receptor protein of the CRL4 E3 ubiquitin ligase (CRL4 CRBN) …

Based on evidence from knockout and transgenic mouse models, human clinical data, and biochemical interactions, we summarize the distinct roles of the CRL4 E3 ligase complexes in …