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Calreticulin (CRT) is a highly conserved and ubiquitously expressed Ca(2+)-binding protein in multicellular eukaryotes. CRT plays a crucial role in many cellular processes including Ca(2+) storage and release, protein synthesis, and molecular chaperone activity. To elucidate the function of CRTs in …

Calreticulin (CRT) is expressed in many cancer cells and plays a role to promote macrophages to engulf hazardous cancerous cells. The reason why most of the cells are not destroyed is the presence of another molecule with signal CD47, which blocks CRT. Hence antibodies that block CD47 might be useful as a cancer treatment.

2019年9月25日 · Calreticulin (CRT) is calcium binding protein of endoplasmic reticulum (ER) which performs plethora of functions besides it's role as molecular chaperone. Among the three different isoforms of this protein, CRT3 is most closely related to primitive CRT gene of higher plants. Based on their distinct …

2024年4月21日 · Calreticulin (CRT) is a calcium-binding endoplasmic reticulum (ER) protein that has been identified for multiple cellular processes, including protein folding, regulation of gene expression, calcium (Ca 2+) storage and signaling, regeneration, and stress responses.

CRT is the gene cluster responsible for the biosynthesis of carotenoids. Those genes are found in eubacteria, [1] in algae [2] and are cryptic in Streptomyces griseus. [3] Carotenoid synthesis is probably present in the common ancestor of Bacteria and Archaea; the phytoene synthase gene crtB is universal among carotenoid synthesizers.

Calreticulin (CRT) is an multifunctional resident endoplasmic reticulum (ER) luminal protein implicated in regulating a variety of cellular processes, including Ca 2+ storage/mobilization and protein folding. These multiple functions may be carried out by …

Calreticulin (CRT) is a protein that is widely distributed in eukaryotic cells. It was first described in the endoplasmic reticulum (ER, a network of interconnected membranes within...

2019年9月25日 · Calreticulin (CRT) is a calcium binding protein found mainly in the endoplasmic reticulum although now it is found to be reported in the nucleus and also in the cytosol. There are three different isoforms of CRT found in plants and the CRT3 isoform is the one which is most closely related to the ancestral plant CRT gene.