2024年12月24日 · CSF3R (Colony Stimulating Factor 3 Receptor) is a Protein Coding gene. Diseases associated with CSF3R include Neutrophilia, Hereditary and Neutropenia, Severe Congenital, 7, Autosomal Recessive. Among its related pathways are Akt Signaling and Signaling by CSF3 (G-CSF).

2024年3月20日 · 在单细胞分析过程中，想要对任何细胞类型进行进一步详细的亚群定义，都需要首先将目的细胞类型完整地从包含有各种其他细胞类型的混合群体中筛选出来，这个时候就需要我们对目的细胞类型的marker十分熟悉。 因此，为了能够更好地从各类细胞类型中筛选出 中性粒细胞，在此首先介绍几篇已发表的人的包含有中性粒细胞的单细胞数据来学习其中的用以定义中性粒细胞的marker。 1. COVID-19 immune features revealed by a large-scale single-cell …

csf3是体内非常重要的细胞生长因子，通过与细胞表面特异性受体g-csfr（csf3r）结合，激活复杂的信号转导系统，发挥多种生物学功能，包括调节粒系的增殖、分化与存活，刺激粒细胞分泌血管内皮生长因子加强血管形成，动员骨髓干细胞至外周血以及诱导干细胞 ...

Activating mutations in the granulocyte colony stimulating factor receptor (CSF3R), cooperate with loss of function mutations in the transcription factor CEBPA to promote acute myeloid leukemia development.

2013年5月9日 · We identified activating mutations in the gene encoding the receptor for colony-stimulating factor 3 (CSF3R) in 16 of 27 patients (59%) with CNL or atypical CML.

集落刺激因子3受体 (colony stimulating factor 3 receptor，CSF3R)是Janus激酶 (Janus kinase，JAK)/信号转导与转录活化因子 (signal transducer and activator of transcription，STAT)和Src/非受体酪氨酸激酶 (tyrosine nonreceptor kinase，TNK)2信号通路相关基因， CSF3R 突变存在于慢性中性粒细胞性白血病 (chronic neutrophilic leukemia，CNL)，严重先天性中性粒细胞减少症 (severe congenital neutropenia，SCN)等髓系肿瘤中。

2025年2月14日 · Colony-stimulating factor 3 receptor gene (CSF3R) encodes the receptor for granulocyte-colony stimulating factor, regulating the activation, proliferation, differentiation, and survival of neutrophils [1].

CSF3R mutations in severe congenital neutropenia and acute myeloid leukemia. Treating SCN patients with G-CSF improves peripheral neutrophil counts and decreases the risk of infections. However, over the long term (10–15 years) improvement in neutrophil counts comes at the cost of an increased risk of leukemic progression from SCN to AML.

2025年1月4日 · Clinical resource with information about CSF3R, Autosomal recessive severe congenital neutropenia due to CSF3R deficiency, Hereditary neutrophilia, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

该基因的突变是导致科斯特曼综合征 (也称为严重先天性中性粒细胞减少症) 的原因。 [RefSeq 提供，2010 年 8 月] The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes.