CT26 is an N-nitroso-N-methylurethane-(NNMU) induced, undifferentiated colon carcinoma cell line. It was cloned to generate the cell line designated CT26.WT (ATCC CRL-2638). Use CT26.WT mouse fibroblasts with CT26.CL25 (ATCC CRL-2639) as a model for testing immunotherapy protocols and in studies on the host immune response.

2016年2月1日 · The CT26 model is highly responsive to anti-CTLA4 antibody treatment with 100% of treated mice showing tumor regressions.

Establishment of mouse colonic carcinoma cell lines with different metastatic properties.

CT26.CL25 is a cell line exhibiting fibroblast-like morphology that was isolated from the large intestine of a mouse with undifferentiated colon carcinoma. This cell line was deposited by N Restifo and can be used in cancer research.

Here, we present an integrated map of the genome, transcriptome and immunome of an epithelial mouse tumor, the CT26 colon carcinoma cell line. We found that Kras is homozygously mutated at p.G12D, Apc and Tp53 are not mutated, and Cdkn2a is homozygously deleted.

In a syngeneic CT26 model, cancer cells from a particular mouse strain are implanted back into mice of the same strain, allowing researchers to study the interaction between the tumor and the immune system in a genetically matched system.

Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen. Highly metastatic variant of a mouse colon carcinoma cell line, LM17 and its response to GM-CSF gene therapy. Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma.

2020年12月1日 · In this model spotlight we will provide data that demonstrate a robust and reproducible orthotopic murine tumor model utilizing CT26.WT colon carcinoma, reliable surgical methods for implantation and validating response to checkpoint inhibition.

Preclinically, the murine CT26 colon carcinoma line has become a platform model for evaluating the potential of drug combinations with immune checkpoint inhibitor antibodies. It is a highly immunogenic tumor and tends to show objective response rates to a number of commercially available checkpoint inhibitors.

CT26.WT (ATCC® CRL-2638 ™) is a murine colorectal carcinoma cell line from a BALB/c mouse. It is a clone of the N-nitroso-N-methylrethane-induced undifferentiated CT26 colon carcinoma cell line. The cells are adherent and have a fibroblast morphology.