最近，来自美国哈佛医学院的Haber教授带领的研究团队发明了一种技术，能够通过检测血液中极微量的肝癌细胞来筛查肝癌的发生。 该技术命名为 微流控CTC-iChip系统 （microfluidic CTC-iChip）。 微流控CTC-iChip系统的工作原理：将抽提的血液放入CTC-iChip微流控装置中，在CTC-iChip微流控装置中首先根据细胞大小将血液中的红细胞、血小板和血浆分离出去，然后利用结合有白细胞CD45、CD16和CD66B抗体的磁珠将白细胞分离出去，经过CTC-iChip微流控装置后血 …

In summary, the CTC-chip is a landmark technology that allows for isolation of large numbers of rare CTCs from the peripheral blood of cancer patients. The unique microfluidic platform holds promise for lung cancer research and clinical management, and in the near future may be used for early detection, monitoring of disease, and genotyping of ...

2020年10月21日 · 2007年，美国麻省总医院癌症中心与强生公司合作，研发出一种能检测出极微量CTC的微流体硅芯片，称为CTC-Chip。 该芯片的表层密布了近8万个包被EpCAM抗体的微位点，当血液样本流过芯片时，该抗体可与肿瘤细胞表面EpCAM相结合从而粘附肿瘤细胞。

Circulating tumor cells (CTCs) are rare cells that originate from a malignancy and circulate freely in the peripheral blood. The ability to capture and study CTCs is an emerging field with implications for early detection, diagnosis, determining prognosis and monitoring of cancer, as well as for und …

2022年12月20日 · We demonstrate MyCTC chip performance by means of spike-in experiments with patient-derived breast circulating tumour cells, enabling >95% capture rates, as well as prospective processing of...

CTC-Chip由78,000个微柱阵列组成，微柱被识别EpCAM的抗体包被，微柱的几何排列和流体流速被优化以促进细胞附着到抗体包被的柱上。 除了CTC-Chip，也有一些公司开发基于微柱结构的芯片富集CTC，如Captura公司的GEDI-Chip，Biocept公司的OncoCEE。

This circulating tumor cell (CTC) chip consists of pillars of different geometries to isolate rare blood cells.

2008年1月11日 · Now, using a silicon microchip the size of a business card, HMS researchers have created a technology that can sift through two milliliters of blood per hour and catch roaming CTCs. The study appears in the Dec. 20 issue of Nature.

2010年10月14日 · 近日马萨诸塞州总医院（MGH）的研究人员在《美国科学院院刊》（PNAS）上发表文章称他们开发出了第二代的CTC芯片（CTC-Chip），并将其命名为HB芯片。 第一代的CTC芯片是一种用于捕获罕见循环肿瘤细胞（CTCs）的设备。

2019年5月14日 · The recently developed NP- HB CTC-Chip allows the release of cells with a chemical ligand-exchange reaction (gold nanoparticle (AuNP)-thiol exchange reaction) and has been engineered to release captured cells from the AuNPs, enabling subsequent CTC molecular analysis, such as next-generation RNA sequencing and ex vivo cell culture [63, 94].