2024年4月1日 · CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs)...

2022年8月2日 · Post-translational modification (PTM) enzymes are CTCF’s partners. (A) CTCF is regulated by three types of PTM, namely, PARylation, SUMOylation, and phosphorylation. (B) PTM sites in CTCF protein, and their roles in modulating CTCF insulator function.

近日，丁俊军实验室在Nature Communications发表了题为 The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation 的研究成果。 该研究...

CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the...

CTCF, which is known to play critical role in chromatin structure, undergoes post-translational modifications (PTMs). In this research, O-GlcNAcylation was found to inhibit CTCF binding, impacting 3D chromatin structure, gene expression and cellular development.

2024年4月1日 · CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of protein to regulate numerous cellular processes.

在这项研究中，我们揭示了 ctcf 的 ptm 分析，并证明 ctcf 可以被 o-glcnac 酰化和精氨酸甲基化。 从功能上讲，我们证明 O-GlcNAc 酰化可抑制 CTCF 与染色质的结合。

CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of protein to regulate numerous cellular processes.

We applied an advanced chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) strategy to comprehensively map higher-order chromosome folding and specific chromatin interactions mediated by CCCTC-binding factor (CTCF) and RNA polymerase II (RNAPII) with haplotype specificity and nucleotide resolution in different human cell linea...

2019年1月24日 · Although previous studies sought to explain CTCF multivalency based on sequence composition of binding sites, few examined how CTCF post-translational modification (PTM) could contribute to function. Here, we performed CTCF mass spectrometry, identified a novel phosphorylation site at Serine 224 (Ser 224 -P), and demonstrate that ...