2024年12月24日 · CTSC (Cathepsin C) is a Protein Coding gene. Diseases associated with CTSC include Papillon-Lefevre Syndrome and Haim-Munk Syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Innate Immune System.

Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo- cysteine protease belonging to the peptidase C1 protein family, a subgroup of the cysteine cathepsins. In humans, it is encoded by the CTSC gene. [5][6]

2024年8月20日 · Cathepsin C (syn. CatC, CTSC), also known as dipeptidyl peptidase I (DPPI), is a lysosomal cysteine protease belonging to the papain-like cysteine peptidases family. As a critical component of the immune system, CTSC plays a dominant role in immune defenses, antimicrobial activity, inflammation, and programmed cell death (apoptosis) [1].

In the mapped region, the causative cathepsin C gene (CTSC) was independently identified by two groups (Hart et al. 1999; Toomes et al. 1999). The CTSC, GenBank accession number NM_001814.4 spans over 46 kb and contains seven exons and six introns (Toomes et al. 1999).

Title: A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome. Cathepsin C Is Involved in Macrophage M1 Polarization via p38/MAPK Pathway in Sudden Cardiac Death.

A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome. Cathepsin C Is Involved in Macrophage M1 Polarization via p38/MAPK Pathway in Sudden Cardiac Death.

2024年8月20日 · Cathepsin C (CTSC) is a lysosomal cysteine protease constitutively expressed at high levels in the lung, kidney, liver, and spleen. It plays a key role in the activation of serine proteases in cytotoxic T cells, natural killer cells (granzymes A and B), mast cells (chymase and tryptase) and neutroph …

该基因编码的蛋白可启动多项功能，包括伴侣绑定活动；氯离子结合活性；和相同的蛋白质结合活性。 涉及多个过程，包括老化；参与细胞蛋白质分解代谢过程的蛋白水解的正调节；和蛋白水解。 位于高尔基体；内质网；和溶酶体。 脑缺血的生物标志物；高血压;和肥胖。 该基因的人类直系同源物与 Papillon-Lefevre 病和侵袭性牙周炎有关。 与人类 CTSC（组织蛋白酶 C）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables several functions, including chaperone binding …

2022年2月2日 · CTSC expression levels in glioma and normal brain tissues, as well as in glioma cells and normal brain cells, was validated by real-time quantitative polymerase chain reaction (RT-qPCR). Gene set enrichment analysis (GSEA) was used to reveal the signaling pathways that CTSC may participate in.

2010年5月24日 · HGNC Approved Gene Symbol: CTSC. Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38) : 11:88,293,592-88,337,736 (from NCBI) Cathepsin C, or dipeptidyl aminopeptidase I (EC 3.4.14.1), is a lysosomal protease capable of removing dipeptides from the amino terminus of protein substrates.