CTSC was heterogeneously expressed across histologic types and tumor grades for diffuse glioma and highly enriched in IDH or IDH1-wildtype glioma. CTSC was positively associated with immune and stromal scores and infiltrating levels of M2 macrophages and neutrophils and negatively associated with infiltrating levels of NK cells.

CTSC overexpression markedly enhanced the growth, motility, and invasiveness of NSCLC cells in vitro and in vivo. CTSC knockdown using shRNA in NSCLC cells reversed the migratory and invasive behavior of NSCLC cells. CTSC also induced epithelial-mesenchymal transition through the Yes-associated protein signaling pathway.

30790-1-AP targets Cathepsin C in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. Cathepsin C, also known as DPP-I.

Cathepsin C(CTSC), a lysosomal cysteine protease abundantly expressed in multiple tissues and belonging to the papain superfamily, plays a pivotal role in numerous tumor biological processes. Moreover, CTSC regulates breast cancer lung metastases by modulating neutrophil infiltration and the formation of neutrophil extracellular traps ...

IHC实验结果显示CTSC在胃癌组织中的表达情况高于配对的癌旁组织。数据分析表明CTSC与多个临床特征之间呈正相关关系。Kaplan-MeierPlotter在线工具分析表明CTSC高表达的患者预后较差。TIMER数据库分析表明CTSC的表达与肿瘤微环境中多种免疫细胞浸润量呈正相关性。

组织蛋白酶 c (ctsc) 是一种溶酶体半胱氨酸蛋白酶，在肺、肾、肝和脾中高水平表达。 它在细胞毒性 T 细胞、自然杀伤细胞（颗粒酶 A 和 B）、肥大细胞（糜酶和类胰蛋白酶）和中性粒细胞（组织蛋白酶 G、中性粒细胞弹性蛋白酶、蛋白酶 3）中丝氨酸蛋白酶的 ...

We aimed to investigate the potential role of CTSC in HCC. HCC tissue microarrays (n=122) were employed to analyze the correlation between CTSC expression and clinicopathological characteristics through immunohistochemistry staining.

2021年1月16日 · 该研究发现 组织蛋白酶C （CTSC） 通过调节中性粒细胞浸润和中性粒细胞胞外陷阱 （NET） 形成促进乳腺癌细胞肺转移 。 在胡国宏研究员的指导下，博士研究生肖炎森、李佳涛、何大洒、丛敏等发现CTSC通过调控转移微环境中中性粒细胞的浸润和NET的形成，促进乳腺癌细胞发生肺转移，证实肿瘤分泌的CTSC可以作为乳腺癌肺转移风险的一个血清学标记和治疗乳腺癌肺转移的新靶点。 研究团队首先通过利用三组遗传学背景相同但具有不同肺转移能力的 …

CTSC was heterogeneously expressed across histologic types and tumor grades for diffuse glioma and highly enriched in IDH or IDH1-wildtype glioma. CTSC was positively associated with immune and stromal scores and infiltrating levels of M2 macrophages and neutrophils and negatively associated with infiltrating levels of NK cells.

2024年8月10日 · CTSC, one of the lysosomal cathepsins, participates in the degradation of intracellular proteins and the processing of certain cathepsins (Bullón et al., 2018). The functional deletion mutation in the CTSC gene may cause Papillon-Lefèvre Syndrome (PLS) by blocking synthesis of CTSC protein hydrolytic active forms (Sanchez Klose et al., 2021).