Cullin-4A is a protein that in humans is encoded by the CUL4A gene. [4] [5] CUL4A belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. …

2024年12月24日 · CUL4A (Cullin 4A) is a Protein Coding gene. Diseases associated with CUL4A include Hematologic Cancer and Xeroderma Pigmentosum, Variant Type. Among its related …

2014年2月1日 · The ability of cullin 4A (CUL4A), a scaffold protein, to recruit a repertoire of substrate adaptors allows it to assemble into distinct E3 ligase complexes to mediate turnover …

2021年11月1日 · Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 in colorectal cancer (CRC) cells, which enhanced PHGDH activity by …

2015年11月23日 · CUL4A, a member of the CULLIN family, functions as a scaffold protein for an E3 ubiquitin ligase. It was reported that the CUL4A gene showed amplification in some human …

CUL4A Antibody detects endogenous levels of total human CUL4A protein. Human, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide …

Cullin4A (CUL4A)是泛素-蛋白酶体系统(ubiquitin-proteasome system,UPS)中泛素E3连接酶家族的重要成员之一.UPS是细胞内蛋白降解的重要途径,越来越多的证据表明CUL4A可以通过CUL4A …

泛素化修饰在肿瘤的发生发展中具有重要作用,其中E3泛素连接酶Cullin 4A (CUL4A)能够通过与DDB1相结合而泛素化多种底物,介导其降解.目前,已经证实在多种肿瘤中均有CUL4A基因的异 …

2006年10月15日 · We found that CUL4A–DDB1 interacts with H3 methylated mononucleosomes and peptides. Inactivation of either CUL4 or DDB1 impairs these histone modifications. …

CUL4A is the ubiquitin Ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]). [supplied by OMIM, …