Cux1 (CUTL1, CDP, CDP/Cux) is a homeodomain protein that in humans is encoded by the CUX1 gene. [3][4][5][6] The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It regulates gene expression, morphogenesis, and differentiation and it also plays a role in cell cycle progression, particularly at S-phase.

2004年11月18日 · CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasiveness in numerous tumor cell lines, both in vitro and in vivo.

cutl1的表达能显著削弱肿瘤细胞在实验性转移模型中的 肺克隆形成率，提示CUTL1的转录活性在肿瘤侵袭转移中 发挥重要作用，并可能增加肿瘤的去分化能力 [8] 。

CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in development and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasiveness …

cutl1表达减少与人类胃癌组织内在抗药性密切相关，可作为一种不良预后生物标记。 功能获得（过表达活性CUTL1）和功能丧失（用CUTL1特异性shRNA抑制）研究证实CUTL1活性增高显着提高了细胞对于药物的敏感性，促进了凋亡。

CUTL1, also known as CDP, Cut, or Cux-1, is a homeodomain transcriptional regulator known to be involved in develop-ment and cell cycle progression. Here we report that CUTL1 activity is associated with increased migration and invasive-ness …

CUTL1, also known as CDP (CCAAT Displacement Protein), Cut, or Cux-1, is a homeodomain transcription factor known to play an essential role in development and cell cycle progression. Previously, we identified CUTL1 as modulator of cell motility and invasiveness.

2013年1月1日 · Human Cutl1, also known as CutX1 or CCAAT displacement protein (cux/CDP), is a transcription factor involved in development and multiple physiological processes. Cutl1 gene spans about 468 kb and generates five distinct transcripts, which results from alternative transcription initiation, splicing and polyadenylation [1].

CUTL1 (Cut-like 1), also known as CUX1 (Cut homeobox 1) (CUX1), is a transcription factor that has been implicated in many cellular processes in different tissues, such as cell migration, neuronal differentiation, and DNA repair (1-5). CUTL1 …

In this review, we systematically analyzed the role of CDP in normal development and tumor progression, and then emphasized its interactors and downstream molecules. Eventually, we concluded that Cut1 could promote cancer progression and its down-regulating expression will be a promising strategy for cancer therapy. Copyright © 2012 Elsevier Inc.