Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene. [5] The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP). [6] It is a protein that is released in large amounts from platelets following their ...

其编码的蛋白质为 趋化因子（C-X-C基序）配体7 Chemokine (C-X-C motif) ligand，是一种CXC 趋化因子 类 细胞因子，其蛋白异型体为 β-血小板球蛋白 或原血小板碱性蛋白（英語： Pro-Platelet basic protein，PPBP） [2]。 这种蛋白在 血小板 活化时被大量释放 [3] ，能刺激多种过程，包括 有丝分裂 、 细胞外基质 的合成、 糖代谢 （英语：glucose metabolism） 和 纤溶酶原激活物 的合成 [4][5]。 ^ Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7).

2023年3月7日 · cxcl7能结合cxcr2，是一种有效的化学诱导剂和中性粒细胞激活剂。研究证明cxcl7/nap-2/ppbp能够刺激各种细胞进程，包括dna合成、有丝分裂、 糖酵解 、细胞内camp积累、前列腺素e2分泌以及透明质酸和硫酸化 糖胺聚糖 的合成。

CXCL7 is a platelet-derived growth factor that belongs to the ELR + CXC chemokine family, functioning as a potent chemoattractant and activator of neutrophils through binding to its receptor CXCR2. CXCL7, a member of the CXC chemokine subfamily, is translated as a proprotein and cleaved into several smaller forms, each with particular functions.

In this review, we summarize the role of CXCL7 in inflammatory diseases and tumors, describe the value of CXCL7 as a diagnostic and prognostic biomarker in inflammatory diseases and cancer, and discuss the importance of CXCL7 and its receptors as therapeutic targets.

CXCL7, also known as neutrophil-activating peptide 2 (NAP-2), is a platelet-derived growth factor that belongs to the CXC chemokine subfamily. It plays a key role in recruiting and activating neutrophils by binding to CXCR2, and is involved in various physiological and pathological processes, including neuroinflammation in conditions like ASD.

2023年7月1日 · CXCL7, also called neutrophil activating peptide 2, is secreted by monocytes and macrophages to promote tumor progression [11, 12]. CXCL8, secreted by macrophages and epithelial cells, is an ...

2022年6月28日 · Over recent years, C-X-C motif ligand 7 (CXCL7) has received widespread attention as a chemokine involved in inflammatory responses. Abnormal production of the chemokine CXCL7 has been identified in different inflammatory diseases; nevertheless, the exact role of CXCL7 in the pathogenesis of inflamm …

研究发现，MM 中 CXCL7 高表达与病理骨折、溶骨性病变相关，它能激活 JAK/STAT3 通路促肿瘤增殖，其高表达还影响患者预后，靶向 CXCL7 或为 MM 新疗法。 CXCL7. 多发性骨髓瘤（MM）是一种难以治愈的恶性肿瘤，具有进展缓慢和高肿瘤内异质性的特点。 MM的临床表现多样，其中溶骨性病变和病理性骨折是多发性骨髓瘤（MM）的标志性表现，严重影响患者的生活质量和预后。 CXCL7是一种趋化因子，属于CXC趋化因子家族，对免疫细胞的迁移和功能有重 …

2025年2月16日 · 为解决类风湿关节炎（RA）治疗难题，北京大学第三医院研究人员开展 CXCL7 在 RA 中作用的研究。 发现 CXCL7 可加重骨破坏，靶向它能缓解病情。 该研究为 RA 治疗提供新思路，强烈推荐科研读者阅读。 北京大学第三医院（Peking University Third Hospital）的研究人员在《Arthritis Research & Therapy》期刊上发表了题为 “CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory …